Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules

doi:10.1084/jem.171.5.1683

This Article

	Full Text (PDF, 906K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Hayashi, S.
	Articles by Nishikawa, S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Hayashi, S.
	Articles by Nishikawa, S.


Social Bookmarking

	What's this?

ARTICLES

Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules

S Hayashi, T Kunisada, M Ogawa, T Sudo, H Kodama, T Suda, S Nishikawa and S Nishikawa
Department of Pathology, Kumamoto University Medical School, Japan.

Growth of early B precursor cells was investigated in vitro by using rIL-7 and IL-7-defective stromal cell line PA6 as separate growth signals. B cell development proceeds through three sequential stages different from the growth signal requirement. The cells in the first stage require PA6 alone for the proliferation, and differentiate into the second stage, which requires both PA6 and IL-7 for its growth. When IL-7 is available for the cells in the second stage, they proliferate extensively on the PA6 layer, and some acquire the ability to proliferate in response to IL-7 alone. This sequential change of growth signal requirement, however, does not proceed autonomously along the time schedule. The possibility that it is primarily directed by the result of Ig gene rearrangement is considered. This mode of growth control may explain why only functional B cells are selected in the error-prone process of Ig gene rearrangement during B lineage differentiation.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Lai, L., Zeff, R. A., Goldschneider, I. (2006). A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells. Blood 107: 1776-1784 [Abstract] [Full Text]
Ikeda, A., Merchant, M., Lev, L., Longnecker, R., Ikeda, M. (2004). Latent Membrane Protein 2A, a Viral B Cell Receptor Homologue, Induces CD5+ B-1 Cell Development. J. Immunol. 172: 5329-5337 [Abstract] [Full Text]
Fry, T. J., Mackall, C. L. (2002). Interleukin-7: from bench to clinic. Blood 99: 3892-3904 [Full Text]
Yamane, T., Kunisada, T., Tsukamoto, H., Yamazaki, H., Niwa, H., Takada, S., Hayashi, S.-I. (2001). Wnt Signaling Regulates Hemopoiesis Through Stromal Cells. J. Immunol. 167: 765-772 [Abstract] [Full Text]
Okada, S., Yoshida, T., Hong, Z., Ishii, G., Hatano, M., Kuro-o, M., Nabeshima, Y., Nabeshima, Y.-i., Tokuhisa, T. (2000). Impairment of B lymphopoiesis in precocious aging (klotho) mice. Int Immunol 12: 861-871 [Abstract] [Full Text]
Tagaya, H., Kunisada, T., Yamazaki, H., Yamane, T., Tokuhisa, T., Wagner, E. F., Sudo, T., Shultz, L. D., Hayashi, S.-I. (2000). Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood 95: 3363-3370 [Abstract] [Full Text]
Smart, F. M., Venkitaraman, A. R. (2000). Inhibition of Interleukin 7 Receptor Signaling by Antigen Receptor Assembly. JEM 191: 737-742 [Abstract] [Full Text]
Marshall, A. J., Fleming, H. E., Wu, G. E., Paige, C. J. (1998). Modulation of the IL-7 Dose-Response Threshold During Pro-B Cell Differentiation Is Dependent on Pre-B Cell Receptor Expression. J. Immunol. 161: 6038-6045 [Abstract] [Full Text]
Nakayama, N., Fang, I., Elliott, G. (1998). Natural Killer and B-Lymphoid Potential in CD34+ Cells Derived From Embryonic Stem Cells Differentiated in the Presence of Vascular Endothelial Growth Factor. Blood 91: 2283-2295 [Abstract] [Full Text]
McKenna, S. D., Chen, F., Lai, L., Goldschneider, I. (1998). Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). I. Production of the Non-IL-7 Component by Bone Marrow Stromal Cells from IL-7 Gene-Deleted Mice. J. Immunol. 160: 2272-2279 [Abstract] [Full Text]
Lai, L., Chen, F., McKenna, S., Goldschneider, I. (1998). Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). II. PPBSF Is a Covalently Linked Heterodimer of IL-7 and a Mr 30,000 Cofactor. J. Immunol. 160: 2280-2286 [Abstract] [Full Text]
Yamane, T., Kunisada, T., Yamazaki, H., Era, T., Nakano, T., Hayashi, S.-I. (1997). Development of Osteoclasts From Embryonic Stem Cells Through a Pathway That Is c-fms but not c-kit Dependent. Blood 90: 3516-3523 [Abstract] [Full Text]
Nutt, S L, Urbanek, P, Rolink, A, Busslinger, M (1997). Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.. Genes Dev. 11: 476-491 [Abstract]
Dorsch, M., Goff, S.�P. (1996). Increased sensitivity to apoptotic stimuli in c-abl-deficient progenitor�B-cell�lines. Proc. Natl. Acad. Sci. USA 93: 13131-13136 [Abstract] [Full Text]
Nakano, T, Kodama, H, Honjo, T (1994). Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 265: 1098-1101 [Abstract]
Spanopoulou, E, Roman, C A, Corcoran, L M, Schlissel, M S, Silver, D P, Nemazee, D, Nussenzweig, M C, Shinton, S A, Hardy, R R, Baltimore, D (1994). Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.. Genes Dev. 8: 1030-1042 [Abstract]
Ogawa, M, Nishikawa, S, Yoshinaga, K, Hayashi, S, Kunisada, T, Nakao, J, Kina, T, Sudo, T, Kodama, H, Nishikawa, S (1993). Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo. Development 117: 1089-1098 [Abstract]