Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen

doi:10.1084/jem.171.5.1469

This Article

	Full Text (PDF, 856K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Scalzo, A. A.
	Articles by Shellam, G. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Scalzo, A. A.
	Articles by Shellam, G. R.


Social Bookmarking

	What's this?

ARTICLES

Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen

AA Scalzo, NA Fitzgerald, A Simmons, AB La Vista and GR Shellam
Department of Microbiology, University of Western Australia, Nedlands.

The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic CMV infection.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Orozco, L. D., Cokus, S. J., Ghazalpour, A., Ingram-Drake, L., Wang, S., van Nas, A., Che, N., Araujo, J. A., Pellegrini, M., Lusis, A. J. (2009). Copy number variation influences gene expression and metabolic traits in mice. Hum Mol Genet 18: 4118-4129 [Abstract] [Full Text]
Geurs, T. L., Zhao, Y. M., Hill, E. B., French, A. R. (2009). Ly49H Engagement Compensates for the Absence of Type I Interferon Signaling in Stimulating NK Cell Proliferation During Murine Cytomegalovirus Infection. J. Immunol. 183: 5830-5836 [Abstract] [Full Text]
Lee, S.-H., Kim, K.-S., Fodil-Cornu, N., Vidal, S. M., Biron, C. A. (2009). Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection. JEM 206: 2235-2251 [Abstract] [Full Text]
Kielczewska, A., Pyzik, M., Sun, T., Krmpotic, A., Lodoen, M. B., Munks, M. W., Babic, M., Hill, A. B., Koszinowski, U. H., Jonjic, S., Lanier, L. L., Vidal, S. M. (2009). Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response. JEM 206: 515-523 [Abstract] [Full Text]
Crough, T., Khanna, R. (2009). Immunobiology of Human Cytomegalovirus: from Bench to Bedside. Clin. Microbiol. Rev. 22: 76-98 [Abstract] [Full Text]
Hsu, K. M., Pratt, J. R., Akers, W. J., Achilefu, S. I., Yokoyama, W. M. (2009). Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. J. Gen. Virol. 90: 33-43 [Abstract] [Full Text]
Fodil-Cornu, N., Lee, S.-H., Belanger, S., Makrigiannis, A. P., Biron, C. A., Buller, R. M., Vidal, S. M. (2008). Ly49h-Deficient C57BL/6 Mice: A New Mouse Cytomegalovirus-Susceptible Model Remains Resistant to Unrelated Pathogens Controlled by the NK Gene Complex. J. Immunol. 181: 6394-6405 [Abstract] [Full Text]
Tripathy, S. K., Keyel, P. A., Yang, L., Pingel, J. T., Cheng, T. P., Schneeberger, A., Yokoyama, W. M. (2008). Continuous engagement of a self-specific activation receptor induces NK cell tolerance. JEM 205: 1829-1841 [Abstract] [Full Text]
Smith, L. M., McWhorter, A. R., Masters, L. L., Shellam, G. R., Redwood, A. J. (2008). Laboratory Strains of Murine Cytomegalovirus Are Genetically Similar to but Phenotypically Distinct from Wild Strains of Virus. J. Virol. 82: 6689-6696 [Abstract] [Full Text]
Davis, A. H., Guseva, N. V., Ball, B. L., Heusel, J. W. (2008). Characterization of Murine Cytomegalovirus m157 from Infected Cells and Identification of Critical Residues Mediating Recognition by the NK Cell Receptor Ly49H. J. Immunol. 181: 265-275 [Abstract] [Full Text]
Bekiaris, V., Timoshenko, O., Hou, T. Z., Toellner, K., Shakib, S., Gaspal, F., McConnell, F. M., Parnell, S. M., Withers, D., Buckley, C. D., Sweet, C., Yokoyama, W. M., Anderson, G., Lane, P. J. L. (2008). Ly49H+ NK Cells Migrate to and Protect Splenic White Pulp Stroma from Murine Cytomegalovirus Infection. J. Immunol. 180: 6768-6776 [Abstract] [Full Text]
Parker, A. K., Yokoyama, W. M., Corbett, J. A., Chen, N., Buller, R. M. L. (2008). Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication. J. Gen. Virol. 89: 751-759 [Abstract] [Full Text]
van Weel, V., Toes, R.E.M., Seghers, L., Deckers, M.M.L., de Vries, M.R., Eilers, P.H., Sipkens, J., Schepers, A., Eefting, D., van Hinsbergh, V.W.M., van Bockel, J.H., Quax, P.H.A. (2007). Natural Killer Cells and CD4+ T-Cells Modulate Collateral Artery Development. Arterioscler. Thromb. Vasc. Bio. 27: 2310-2318 [Abstract] [Full Text]
Klenovsek, K., Weisel, F., Schneider, A., Appelt, U., Jonjic, S., Messerle, M., Bradel-Tretheway, B., Winkler, T. H., Mach, M. (2007). Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells. Blood 110: 3472-3479 [Abstract] [Full Text]
Munks, M. W., Pinto, A. K., Doom, C. M., Hill, A. B. (2007). Viral Interference with Antigen Presentation Does Not Alter Acute or Chronic CD8 T Cell Immunodominance in Murine Cytomegalovirus Infection. J. Immunol. 178: 7235-7241 [Abstract] [Full Text]
Parker, A. K., Parker, S., Yokoyama, W. M., Corbett, J. A., Buller, R. M. L. (2007). Induction of Natural Killer Cell Responses by Ectromelia Virus Controls Infection. J. Virol. 81: 4070-4079 [Abstract] [Full Text]
Wagner, C. S., Riise, G. C., Bergstrom, T., Karre, K., Carbone, E., Berg, L. (2007). Increased Expression of Leukocyte Ig-Like Receptor-1 and Activating Role of UL18 in the Response to Cytomegalovirus Infection. J. Immunol. 178: 3536-3543 [Abstract] [Full Text]
Corbett, A. J., Forbes, C. A., Moro, D., Scalzo, A. A. (2007). Extensive sequence variation exists among isolates of murine cytomegalovirus within members of the m02 family of genes. J. Gen. Virol. 88: 758-769 [Abstract] [Full Text]
French, A. R., Sjolin, H., Kim, S., Koka, R., Yang, L., Young, D. A., Cerboni, C., Tomasello, E., Ma, A., Vivier, E., Karre, K., Yokoyama, W. M. (2006). DAP12 Signaling Directly Augments Proproliferative Cytokine Stimulation of NK Cells during Viral Infections. J. Immunol. 177: 4981-4990 [Abstract] [Full Text]
Adam, S. G., Caraux, A., Fodil-Cornu, N., Loredo-Osti, J. C., Lesjean-Pottier, S., Jaubert, J., Bubic, I., Jonjic, S., Guenet, J.-L., Vidal, S. M., Colucci, F. (2006). Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice. J. Immunol. 176: 5478-5485 [Abstract] [Full Text]
Dighe, A., Rodriguez, M., Sabastian, P., Xie, X., McVoy, M., Brown, M. G. (2005). Requisite H2k Role in NK Cell-Mediated Resistance in Acute Murine Cytomegalovirus-Infected MA/My Mice. J. Immunol. 175: 6820-6828 [Abstract] [Full Text]
Pao, L. I., Sumaria, N., Kelly, J. M., Dommelen, S. v., Cretney, E., Wallace, M. E., Anthony, D. A., Uldrich, A. P., Godfrey, D. I., Papadimitriou, J. M., Mullbacher, A., Degli-Esposti, M. A., Smyth, M. J. (2005). Functional Analysis of Granzyme M and Its Role in Immunity to Infection. J. Immunol. 175: 3235-3243 [Abstract] [Full Text]
Williams, A. P., Bateman, A. R., Khakoo, S. I. (2005). HANGING IN THE BALANCE: KIR and Their Role in Disease. Mol. Interv. 5: 226-240 [Abstract] [Full Text]
Hasan, M., Krmpotic, A., Ruzsics, Z., Bubic, I., Lenac, T., Halenius, A., Loewendorf, A., Messerle, M., Hengel, H., Jonjic, S., Koszinowski, U. H. (2005). Selective Down-Regulation of the NKG2D Ligand H60 by Mouse Cytomegalovirus m155 Glycoprotein. J. Virol. 79: 2920-2930 [Abstract] [Full Text]
Redwood, A. J., Messerle, M., Harvey, N. L., Hardy, C. M., Koszinowski, U. H., Lawson, M. A., Shellam, G. R. (2005). Use of a Murine Cytomegalovirus K181-Derived Bacterial Artificial Chromosome as a Vaccine Vector for Immunocontraception. J. Virol. 79: 2998-3008 [Abstract] [Full Text]
Rodriguez, M., Sabastian, P., Clark, P., Brown, M. G. (2004). Cmv1-Independent Antiviral Role of NK Cells Revealed in Murine Cytomegalovirus-Infected New Zealand White Mice. J. Immunol. 173: 6312-6318 [Abstract] [Full Text]
Halford, W. P., Balliet, J. W., Gebhardt, B. M. (2004). Re-Evaluating Natural Resistance to Herpes Simplex Virus Type 1. J. Virol. 78: 10086-10095 [Abstract] [Full Text]
Khakoo, S. I., Thio, C. L., Martin, M. P., Brooks, C. R., Gao, X., Astemborski, J., Cheng, J., Goedert, J. J., Vlahov, D., Hilgartner, M., Cox, S., Little, A.-M., Alexander, G. J., Cramp, M. E., O'Brien, S. J., Rosenberg, W. M. C., Thomas, D. L., Carrington, M. (2004). HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection. Science 305: 872-874 [Abstract] [Full Text]
Bubic, I., Wagner, M., Krmpotic, A., Saulig, T., Kim, S., Yokoyama, W. M., Jonjic, S., Koszinowski, U. H. (2004). Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus. J. Virol. 78: 7536-7544 [Abstract] [Full Text]
Voigt, V., Forbes, C. A., Tonkin, J. N., Degli-Esposti, M. A., Smith, H. R. C., Yokoyama, W. M., Scalzo, A. A. (2003). Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells. Proc. Natl. Acad. Sci. USA 100: 13483-13488 [Abstract] [Full Text]
Lundberg, P., Welander, P., Openshaw, H., Nalbandian, C., Edwards, C., Moldawer, L., Cantin, E. (2003). A Locus on Mouse Chromosome 6 That Determines Resistance to Herpes Simplex Virus Also Influences Reactivation, While an Unlinked Locus Augments Resistance of Female Mice. J. Virol. 77: 11661-11673 [Abstract] [Full Text]
Lee, S.-H., Zafer, A., de Repentigny, Y., Kothary, R., Tremblay, M. L., Gros, P., Duplay, P., Webb, J. R., Vidal, S. M. (2003). Transgenic Expression of the Activating Natural Killer Receptor Ly49H Confers Resistance to Cytomegalovirus in Genetically Susceptible Mice. JEM 197: 515-526 [Abstract] [Full Text]
Smith, H. R. C., Heusel, J. W., Mehta, I. K., Kim, S., Dorner, B. G., Naidenko, O. V., Iizuka, K., Furukawa, H., Beckman, D. L., Pingel, J. T., Scalzo, A. A., Fremont, D. H., Yokoyama, W. M. (2002). Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc. Natl. Acad. Sci. USA 99: 8826-8831 [Abstract] [Full Text]
Wang, E. C. Y., McSharry, B., Retiere, C., Tomasec, P., Williams, S., Borysiewicz, L. K., Braud, V. M., Wilkinson, G. W. G. (2002). From the Cover: UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proc. Natl. Acad. Sci. USA 99: 7570-7575 [Abstract] [Full Text]
Arase, H., Mocarski, E. S., Campbell, A. E., Hill, A. B., Lanier, L. L. (2002). Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors. Science 296: 1323-1326 [Abstract] [Full Text]
Oliveira, S. A., Park, S.-H., Lee, P., Bendelac, A., Shenk, T. E. (2002). Murine Cytomegalovirus m02 Gene Family Protects against Natural Killer Cell-Mediated Immune Surveillance. J. Virol. 76: 885-894 [Abstract] [Full Text]
Spindler, K. R., Fang, L., Moore, M. L., Hirsch, G. N., Brown, C. C., Kajon, A. (2001). SJL/J Mice Are Highly Susceptible to Infection by Mouse Adenovirus Type 1. J. Virol. 75: 12039-12046 [Abstract] [Full Text]
Dokun, A. O., Chu, D. T., Yang, L., Bendelac, A. S., Yokoyama, W. M. (2001). Analysis of In Situ NK Cell Responses During Viral Infection. J. Immunol. 167: 5286-5293 [Abstract] [Full Text]
Thach, D. C., Kleeberger, S. R., Tucker, P. C., Griffin, D. E. (2001). Genetic Control of Neuroadapted Sindbis Virus Replication in Female Mice Maps to Chromosome 2 and Associates with Paralysis and Mortality. J. Virol. 75: 8674-8680 [Abstract] [Full Text]
Daniels, K. A., Devora, G., Lai, W. C., O'Donnell, C. L., Bennett, M., Welsh, R. M. (2001). Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h. JEM 194: 29-44 [Abstract] [Full Text]
Pereira, R. A., Scalzo, A., Simmons, A. (2001). Cutting Edge: A NK Complex-Linked Locus Governs Acute Versus Latent Herpes Simplex Virus Infection of Neurons. J. Immunol. 166: 5869-5873 [Abstract] [Full Text]
Brown, M. G., Dokun, A. O., Heusel, J. W., Smith, H. R. C., Beckman, D. L., Blattenberger, E. A., Dubbelde, C. E., Stone, L. R., Scalzo, A. A., Yokoyama, W. M. (2001). Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection. Science 292: 934-937 [Abstract] [Full Text]
Dietrich, W. F. (2001). Using Mouse Genetics to Understand Infectious Disease Pathogenesis. Genome Res 11: 325-331 [Full Text]
Andrews, D. M., Farrell, H. E., Densley, E. H., Scalzo, A. A., Shellam, G. R., Degli-Esposti, M. A. (2001). NK1.1+ Cells and Murine Cytomegalovirus Infection: What Happens In Situ?. J. Immunol. 166: 1796-1802 [Abstract] [Full Text]
Cerboni, C., Mousavi-Jazi, M., Linde, A., Soderstrom, K., Brytting, M., Wahren, B., Karre, K., Carbone, E. (2000). Human Cytomegalovirus Strain-Dependent Changes in NK Cell Recognition of Infected Fibroblasts. J. Immunol. 164: 4775-4782 [Abstract] [Full Text]
Tomasec, P., Braud, V. M., Rickards, C., Powell, M. B., McSharry, B. P., Gadola, S., Cerundolo, V., Borysiewicz, L. K., McMichael, A. J., Wilkinson, G. W. (2000). Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40. Science 287: 1031-1033 [Abstract] [Full Text]
Depatie, C., Chalifour, A., Pare, C., Lee, S.-H., Vidal, S. M., Lemieux3, S. (1999). Assessment of Cmv1 candidates by genetic mapping and in vivo antibody depletion of NK cell subsets. Int Immunol 11: 1541-1551 [Abstract] [Full Text]
Brown, M. G., Zhang, J., Du, Y., Stoll, J., Yokoyama, W. M., Scalzo, A. A. (1999). Localization on a Physical Map of the NKC-Linked Cmv1 Locus Between Ly49b and the Prp Gene Cluster on Mouse Chromosome 6. J. Immunol. 163: 1991-1999 [Abstract] [Full Text]
Tay, C. H., Yu, L. Y. Y., Kumar, V., Mason, L., Ortaldo, J. R., Welsh, R. M. (1999). The Role of LY49 NK Cell Subsets in the Regulation of Murine Cytomegalovirus Infections. J. Immunol. 162: 718-726 [Abstract] [Full Text]
Idris, A. H., Iizuka, K., Smith, H. R.C., Scalzo, A. A., Yokoyama, W. M. (1998). Genetic Control Of Natural Killing and In Vivo Tumor Elimination by the Chok Locus. JEM 188: 2243-2256 [Abstract] [Full Text]
Polic, B., Hengel, H., Krmpotic, A., Trgovcich, J., Pavic, I., Lucin, P., Jonjic, S., Koszinowski, U. H. (1998). Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection. JEM 188: 1047-1054 [Abstract] [Full Text]
Holtappels, R., Podlech, J., Geginat, G., Steffens, H.-P., Thomas, D., Reddehase, M. J. (1998). Control of Murine Cytomegalovirus in the Lungs: Relative but Not Absolute Immunodominance of the Immediate-Early 1�Nonapeptide during the Antiviral Cytolytic T-Lymphocyte Response in Pulmonary Infiltrates. J. Virol. 72: 7201-7212 [Abstract] [Full Text]
Sjolin, H., Tomasello, E., Mousavi-Jazi, M., Bartolazzi, A., Karre, K., Vivier, E., Cerboni, C. (2002). Pivotal Role of KARAP/DAP12 Adaptor Molecule in the Natural Killer Cell-mediated Resistance to Murine Cytomegalovirus Infection. JEM 195: 825-834 [Abstract] [Full Text]