Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities

doi:10.1084/jem.171.3.935

This Article

	Full Text (PDF, 367K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Roberts, J. L.
	Articles by Singer, A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Roberts, J. L.
	Articles by Singer, A.


Social Bookmarking

	What's this?

ARTICLES

Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities

JL Roberts, SO Sharrow and A Singer
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

The present study demonstrates that immune tolerance can be achieved in the thymus both by clonal deletion and by clonal inactivation, but that the two tolerant states are induced by cellular elements with different radiation sensitivities. TCR engagement of self antigens on bone marrow- derived, radiation-sensitive (presumably dendritic) cells induces clonal deletion of developing thymocytes, whereas TCR engagement of self antigens on radiation-resistant cellular elements, such as thymic epithelium, induces clonal anergy. The nondeleted, anergic thymocytes can express IL-2-Rs but are unable to proliferate in response to either specific antigen or anti-TCR antibodies, and do develop into phenotypically mature cells that emigrate out of the thymus and into the periphery.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Chen, X., Fang, L., Song, S., Guo, T. B., Liu, A., Zhang, J. Z. (2009). Thymic Regulation of Autoimmune Disease by Accelerated Differentiation of Foxp3+ Regulatory T Cells through IL-7 Signaling Pathway. J. Immunol. 183: 6135-6144 [Abstract] [Full Text]
Rubin, R. L., Hermanson, T. M. (2005). Plasticity in the positive selection of T cells: affinity of the selecting antigen and IL-7 affect T cell responsiveness. Int Immunol 17: 959-971 [Abstract] [Full Text]
Viret, C., Janeway, C. A. Jr. (2003). Self-Specific MHC Class II-Restricted CD4-CD8- T Cells That Escape Deletion and Lack Regulatory Activity. J. Immunol. 170: 201-209 [Abstract] [Full Text]
Berg, R. E., Irion, S., Kattman, S., Princiotta, M. F., Staerz, U. D. (2000). A Physiological Ligand of Positive Selection Is Recognized as a Weak Agonist. J. Immunol. 165: 4209-4216 [Abstract] [Full Text]
Chaturvedi, P., Agrawal, B., Zechel, M., Lee-Chan, E., Singh, B. (2000). A Self MHC Class II {beta}-Chain Peptide Prevents Diabetes in Nonobese Diabetic Mice. J. Immunol. 164: 6610-6620 [Abstract] [Full Text]
Kimura, M., Yamashita, M., Kubo, M., Iwashima, M., Shimizu, C., Tokoyoda, K., Chiba, J., Taniguchi, M., Katsumata, M., Nakayama, T. (2000). Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells. Int Immunol 12: 817-824 [Abstract] [Full Text]
Pardigon, N., Cambouris, C., Bercovici, N., Lemaitre, F., Liblau, R., Kourilsky, P. (2000). Delayed and Separate Costimulation In Vitro Supports the Evidence of a Transient ""Excited"" State of CD8+ T Cells During Activation. J. Immunol. 164: 4493-4499 [Abstract] [Full Text]
Irion, S., Berg, R. E., Staerz, U. D. (2000). A Physiological Ligand of Positive Selection Is Seen with High Specificity. J. Immunol. 164: 4601-4606 [Abstract] [Full Text]
van Meerwijk, J. P.M., MacDonald, H. R. (1999). In Vivo T-Lymphocyte Tolerance in the Absence of Thymic Clonal Deletion Mediated by Hematopoietic Cells. Blood 93: 3856-3862 [Abstract] [Full Text]
Itoh, M., Takahashi, T., Sakaguchi, N., Kuniyasu, Y., Shimizu, J., Otsuka, F., Sakaguchi, S. (1999). Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance. J. Immunol. 162: 5317-5326 [Abstract] [Full Text]
Dubois, P. M., Pihlgren, M., Tomkowiak, M., Van Mechelen, M., Marvel, J. (1998). Tolerant CD8 T Cells Induced by Multiple Injections of Peptide Antigen Show Impaired TCR Signaling and Altered Proliferative Responses In Vitro and In Vivo. J. Immunol. 161: 5260-5267 [Abstract] [Full Text]
Colson, Y. L., Tripp, R. A., Doherty, P. C., Wren, S. M., Neipp, M., Abou El-Ezz, A. Y., Ildstad, S. T. (1998). Antiviral Cytotoxic Activity Across a Species Barrier in Mixed Xenogeneic Chimeras: Functional Restriction to Host MHC. J. Immunol. 160: 3790-3796 [Abstract] [Full Text]
Staples, J. E., Murante, F. G., Fiore, N. C., Gasiewicz, T. A., Silverstone, A. E. (1998). Thymic Alterations Induced by 2,3,7,8-Tetrachlorodibenzo- p-Dioxin Are Strictly Dependent on Aryl Hydrocarbon Receptor Activation in Hemopoietic Cells. J. Immunol. 160: 3844-3854 [Abstract] [Full Text]
Ramsdell, F., Fowlkes, B. J. (1992). Maintenance of in Vivo Tolerance by Persistence of Antigen. Science 257: 1130-1134 [Abstract]
Otten, G., Germain, R. (1991). Split anergy in a CD8+ T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science 251: 1228-1231 [Abstract]
Jones, L., Chin, L., Longo, D., Kruisbeek, A. (1990). Peripheral clonal elimination of functional T cells. Science 250: 1726-1729 [Abstract]
Ramsdell, F, Fowlkes, B. (1990). Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance. Science 248: 1342-1348 [Abstract]
Sprent, J, Gao, E., Webb, S. (1990). T cell reactivity to MHC molecules: immunity versus tolerance. Science 248: 1357-1363 [Abstract]