Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection

doi:10.1084/jem.171.1.307

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Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection

CP Larsen, PJ Morris and JM Austyn
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom.

It has been a long-standing dogma that host sensitization against fully- vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.
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