The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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Journal of Experimental Medicine, Vol 171, 221-230, Copyright © 1990 by Rockefeller University Press

ARTICLES

Allelic variations in the human T cell receptor V beta 6.7 gene products [published erratum appears in J Exp Med 1990 Mar 1;171(3):973]

Y Li, P Szabo, MA Robinson, B Dong and DN Posnett
Department of Medicine, Cornell University Medical College, New York, New York 10021.

Polymorphisms of human TCR gene products have been suggested by the description of a mAb, OT145, that identifies a subset of TCRs in some individuals but not in others (6). Here we demonstrate that this mAb detects a TCR allotype of the V beta 6.7 gene. Two allelic products of this V gene differ by two nonconservative amino acid substitutions. The mAb OT145 appears to react with V beta 6.7 a gene products ("+" allele), but not with V beta 6.7b gene products ("-" allele). This represents the first direct demonstration that TCR V gene allotypes exist and provides a possible explanation for immune responses under the control of TCR V genes and for disease associations with TCR V genes.
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