Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells

doi:10.1084/jem.170.5.1751

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Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells

R Peleman, J Wu, C Fargeas and G Delespesse
Notre-Dame Hospital Research Center, University of Montreal, Quebec, Canada.

rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production of IL-4 and IFN-gamma may be significantly influenced by the chronological order of activation of their respective gene.
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