Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia

doi:10.1084/jem.170.5.1627

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Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia

Y Fong, KJ Tracey, LL Moldawer, DG Hesse, KB Manogue, JS Kenney, AT Lee, GC Kuo, AC Allison and SF Lowry
Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021.

Cytokines secreted in response to invading micro-organisms are important mediators of detrimental hemodynamic and metabolic changes in the host. To test whether cachectin/TNF plays a role in triggering release of other cytokines in the setting of infection, anesthetized baboons were passively immunized against systemic cachectin/TNF before infusion of a LD100 dose of live Escherichia coli. Bacteremia led to significant increases in circulating levels of cachectin/TNF, IL-1 beta, and IL-6. Although bacterial endotoxin/lipopolysaccharide is a potent stimulus for the synthesis and release of IL-1 and IL-6 in vitro, specific neutralization of cachectin/TNF in vivo with mAb pretreatment significantly attenuated both the IL-1 beta and the IL-6 responses despite fulminant overwhelming bacteremia. These data suggest that cachectin/TNF is essential for the initiation or amplification of IL-1 and IL-6 release during lethal gram-negative septic shock syndrome.
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Smith, M. V., Lee, M. J., Islam, A. S., Rohrer, J. L., Goldberg, V. M., Beidelschies, M. A., Greenfield, E. M. (2007). Inhibition of the PI3K-Akt Signaling Pathway Reduces Tumor Necrosis Factor-{alpha} Production in Response to Titanium Particles in Vitro. JBJS 89: 1019-1027 [Abstract] [Full Text]
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Cavaillon, J.-M., Annane, D. (2006). Invited review: Compartmentalization of the inflammatory response in sepsis and SIRS. Innate Immunity 12: 151-170 [Abstract]
Feldmann, M., Pusey, C. D. (2006). Is There a Role for TNF-{alpha} in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis? Lessons from Other Chronic Inflammatory Diseases. J. Am. Soc. Nephrol. 17: 1243-1252 [Abstract] [Full Text]
Papasian, C. J., Qureshi, N., Morrison, D. C. (2006). Endogenous and exogenous glucocorticoids in experimental enterococcal infection.. CVI 13: 349-355 [Abstract] [Full Text]
Nissinen, R, Leirisalo-Repo, M, Peltomaa, R, Palosuo, T, Vaarala, O (2004). Cytokine and chemokine receptor profile of peripheral blood mononuclear cells during treatment with infliximab in patients with active rheumatoid arthritis. Ann Rheum Dis 63: 681-687 [Abstract] [Full Text]
Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H. E., Susarla, S. M., Ulloa, L., Wang, H., DiRaimo, R., Czura, C. J., Wang, H., Roth, J., Warren, H. S., Fink, M. P., Fenton, M. J., Andersson, U., Tracey, K. J. (2004). Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc. Natl. Acad. Sci. USA 101: 296-301 [Abstract] [Full Text]
Shiratori, K., Ohgami, K., Ilieva, I. B., Koyama, Y., Yoshida, K., Ohno, S. (2004). Inhibition of Endotoxin-Induced Uveitis and Potentiation of Cyclooxygenase-2 Protein Expression by {alpha}-Melanocyte-Stimulating Hormone. IOVS 45: 159-164 [Abstract] [Full Text]
Kariagina, A., Romanenko, D., Ren, S.-G., Chesnokova, V. (2004). Hypothalamic-Pituitary Cytokine Network. Endocrinology 145: 104-112 [Abstract] [Full Text]
Goon, P. K. C., Igakura, T., Hanon, E., Mosley, A. J., Asquith, B., Gould, K. G., Taylor, G. P., Weber, J. N., Bangham, C. R. M. (2003). High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4+ T Cells in Patients with HTLV-1-Associated Neurological Disease. J. Virol. 77: 9716-9722 [Abstract] [Full Text]
Reading, P. C., Moore, J. B., Smith, G. L. (2003). Steroid Hormone Synthesis by Vaccinia Virus Suppresses the Inflammatory Response to Infection. JEM 197: 1269-1278 [Abstract] [Full Text]
Papasian, C. J., Silverstein, R., Gao, J. J., Bamberger, D. M., Morrison, D. C. (2002). Anomalous Role of Tumor Necrosis Factor Alpha in Experimental Enterococcal Infection. Infect. Immun. 70: 6628-6637 [Abstract] [Full Text]
Oguri, S., Motegi, K., Iwakura, Y., Endo, Y. (2002). Primary Role of Interleukin-1{alpha} and Interleukin-1{beta} in Lipopolysaccharide-Induced Hypoglycemia in Mice. CVI 9: 1307-1312 [Abstract] [Full Text]
Khan, A. Q., Shen, Y., Wu, Z.-Q., Wynn, T. A., Snapper, C. M. (2002). Endogenous Pro- and Anti-Inflammatory Cytokines Differentially Regulate an In Vivo Humoral Response to Streptococcus pneumoniae. Infect. Immun. 70: 749-761 [Abstract] [Full Text]
KANEHIRO, A., LAHN, M., MAKELA, M. J., DAKHAMA, A., FUJITA, M., JOETHAM, A., MASON, R. J., BORN, W., GELFAND, E. W. (2001). Tumor Necrosis Factor-alpha Negatively Regulates Airway Hyperresponsiveness through gamma delta T Cells. Am. J. Respir. Crit. Care Med. 164: 2229-2238 [Abstract] [Full Text]
HACKETT, S.J., THOMSON, A.P. J., HART, C.A. (2001). Cytokines, chemokines and other effector molecules involved in meningococcal disease. J Med Microbiol 50: 847-859 [Abstract] [Full Text]
Czura, C. J., Haichao Wang, , Tracey, K. J. (2001). Dual roles for HMGB1: DNA binding and cytokine. Innate Immunity 7: 315-321 [Abstract]
Kadokami, T., McTiernan, C. F., Kubota, T., Frye, C. S., Bounoutas, G. S., Robbins, P. D., Watkins, S. C., Feldman, A. M. (2001). Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression. Am. J. Physiol. Heart Circ. Physiol. 280: H2281-H2291 [Abstract] [Full Text]
Milligan, E. D., O'Connor, K. A., Nguyen, K. T., Armstrong, C. B., Twining, C., Gaykema, R. P. A., Holguin, A., Martin, D., Maier, S. F., Watkins, L. R. (2001). Intrathecal HIV-1 Envelope Glycoprotein gp120 Induces Enhanced Pain States Mediated by Spinal Cord Proinflammatory Cytokines. J. Neurosci. 21: 2808-2819 [Abstract] [Full Text]
Moreland, J. G., Fuhrman, R. M., Wohlford-Lenane, C. L., Quinn, T. J., Benda, E., Pruessner, J. A., Schwartz, D. A. (2001). TNF-{alpha} and IL-1{beta} are not essential to the inflammatory response in LPS-induced airway disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L173-L180 [Abstract] [Full Text]
Walzl, G., Tafuro, S., Moss, P., Openshaw, P. J.M., Hussell, T. (2000). Influenza Virus Lung Infection Protects from Respiratory Syncytial Virus-Induced Immunopathology. JEM 192: 1317-1326 [Abstract] [Full Text]
Lauw, F. N., Pajkrt, D., Hack, C. E., Kurimoto, M., van Deventer, S. J. H., van der Poll, T. (2000). Proinflammatory Effects of IL-10 During Human Endotoxemia. J. Immunol. 165: 2783-2789 [Abstract] [Full Text]
Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., Tracey, K. J. (2000). High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes. JEM 192: 565-570 [Abstract] [Full Text]
Laye, S., Gheusi, G., Cremona, S., Combe, C., Kelley, K., Dantzer, R., Parnet, P. (2000). Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279: R93-R98 [Abstract] [Full Text]
Zhang, Y., Pilon, G., Marette, A., Baracos, V. E. (2000). Cytokines and endotoxin induce cytokine receptors in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 279: E196-E205 [Abstract] [Full Text]
Nadeau, S., Rivest, S. (2000). Role of Microglial-Derived Tumor Necrosis Factor in Mediating CD14 Transcription and Nuclear Factor kappa B Activity in the Brain during Endotoxemia. J. Neurosci. 20: 3456-3468 [Abstract] [Full Text]
Dekkers, P. E. P., ten Hove, T., te Velde, A. A., van Deventer, S. J. H., van der Poll, T. (2000). Upregulation of Monocyte Urokinase Plasminogen Activator Receptor during Human Endotoxemia. Infect. Immun. 68: 2156-2160 [Abstract] [Full Text]
Minnema, M. C., Chang, A. C. K., Jansen, P. M., Lubbers, Y. T. P., Pratt, B. M., Whittaker, B. G., Taylor, F. B., Hack, C. E., Friedman, B. (2000). Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli. Blood 95: 1117-1123 [Abstract] [Full Text]
Rivest, S., Lacroix, S., Vallières, L., Nadeau, S., Zhang, J., Laflamme, N. (2000). How the Blood Talks to the Brain Parenchyma and the Paraventricular Nucleus of the Hypothalamus During Systemic Inflammatory and Infectious Stimuli. Exp. Biol. Med. 223: 22-38 [Abstract] [Full Text]
Maxwell, J. R., Weinberg, A., Prell, R. A., Vella, A. T. (2000). Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion. J. Immunol. 164: 107-112 [Abstract] [Full Text]
Rayhane, N., Fitting, C., Cavaillon, J.-M. (1999). Dissociation of IFN-{gamma} from IL-12 and IL-18 production during endotoxin tolerance. Innate Immunity 5: 319-324 [Abstract]
Segura, M., Stankova, J., Gottschalk, M. (1999). Heat-Killed Streptococcus suis Capsular Type 2 Strains Stimulate Tumor Necrosis Factor Alpha and Interleukin-6 Production by Murine Macrophages. Infect. Immun. 67: 4646-4654 [Abstract] [Full Text]
Cartmell, T, Luheshi, G N, Rothwell, N J (1999). Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. J. Physiol. 518: 585-594 [Abstract] [Full Text]
Dinarello, C. A. (1999). Blocking IL-1 and TNF. Innate Immunity 5: 174-176
Sumida, M., Inaba, H., Isawa, E., Fujimoto, S., Satoh, T., Kawamata, M. (1999). Prevention by Methylprednisolone of Increased Circulating Tumor Necrosis Factor-{alpha} Levels and Lung Injury Associated with Systemic Inflammatory Response Syndrome due to Intraperitoneal Hyperthermia. Anesth. Analg. 88: 771-771 [Abstract] [Full Text]
Yamashita, K., Takahashi, A., Kobayashi, S., Hirata, H., Mesner, P. W. Jr, Kaufmann, S. H., Yonehara, S., Yamamoto, K., Uchiyama, T., Sasada, M. (1999). Caspases Mediate Tumor Necrosis Factor-alpha -Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production. Blood 93: 674-685 [Abstract] [Full Text]
Soltys, J., Quinn, M. T. (1999). Modulation of Endotoxin- and Enterotoxin-Induced Cytokine Release by In Vivo Treatment with beta -(1,6)-Branched beta -(1,3)-Glucan. Infect. Immun. 67: 244-252 [Abstract] [Full Text]
Voisin, L., Breuille, D., Ruot, B., Ralliere, C., Rambourdin, F., Dalle, M., Obled, C. (1998). Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 275: R1412-R1419 [Abstract] [Full Text]
Ksontini, R., MacKay, S. L. D., Moldawer, L. L. (1998). Revisiting the Role of Tumor Necrosis Factor {alpha} and the Response to Surgical Injury and Inflammation. Arch Surg 133: 558-567 [Abstract] [Full Text]
Solorzano, C. C., Kaibara, A., Hess, P. J., Edwards, P. D., Ksontini, R., Abouhamze, A., McDaniel, S., Frazier, J., Trujillo, D., Kieft, G., Seely, J., Kohno, T., Cosenza, M. E., Clare-Salzler, M., MacKay, S. L.�D., Martin, S. W., Moldawer, L. L., Edwards, C. K. III (1998). Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon. J. Appl. Physiol. 84: 1119-1130 [Abstract] [Full Text]
Turnbull, A. V., Rivier, C. L. (1998). Intracerebroventricular Passive Immunization. I. The Effect of Intracerebroventricular Administration of an Antiserum to Tumor Necrosis Factor-{alpha} on the Plasma Adrenocorticotropin Response to Lipopolysaccharide in Rats. Endocrinology 139: 119-127 [Abstract] [Full Text]
Jansen, P. M., Eisele, B., de Jong, I. W., Chang, A., Delvos, U., Taylor, F. B. Jr., Hack, C. E. (1998). Effect of C1 Inhibitor on Inflammatory and Physiologic Response Patterns in Primates Suffering from Lethal Septic Shock. J. Immunol. 160: 475-484 [Abstract] [Full Text]
Forfia, P. R., Zhang, X., Ochoa, F., Ochoa, M., Xu, X., Bernstein, R., Sehgal, P. B., Ferreri, N. R., Hintze, T. H. (1998). Relationship between plasma NOx and cardiac and vascular dysfunction after LPS injection in anesthetized dogs. Am. J. Physiol. Heart Circ. Physiol. 274: H193-H201 [Abstract] [Full Text]
Van Der Poll, T., Lowry, S. F. (1997). Epinephrine inhibits endotoxin-induced IL-1beta production: roles of tumor necrosis factor-alpha and IL-10. Am. J. Physiol. Regul. Integr. Comp. Physiol. 273: R1885-R1890 [Abstract] [Full Text]
Rowe, J., Finlay-Jones, J. J., Nicholas, T. E., Bowden, J., Morton, S., Hart, P. H. (1997). Inability of Histamine to Regulate TNF-alpha Production by Human Alveolar Macrophages. Am. J. Respir. Cell Mol. Bio. 17: 218-226 [Abstract] [Full Text]
Abraham, E., Glauser, M. P., Butler, T., Garbino, J., Gelmont, D., Laterre, P. F., Kudsk, K., Bruining, H. A., Otto, C., Tobin, E., Zwingelstein, C., Lesslauer, W., Leighton, A. (1997). p55 Tumor Necrosis Factor Receptor Fusion Protein in the Treatment of Patients With Severe Sepsis and Septic Shock: A Randomized Controlled Multicenter Trial. JAMA 277: 1531-1538 [Abstract]
Turnbull, A. V., Pitossi, F. J., Lebrun, J.-J., Lee, S., Meltzer, J. C., Nance, D. M., del Rey, A., Besedovsky, H. O., Rivier, C. (1997). Inhibition of Tumor Necrosis Factor-alpha Action within the CNS Markedly Reduces the Plasma Adrenocorticotropin Response to Peripheral Local Inflammation in Rats. J. Neurosci. 17: 3262-3273 [Abstract] [Full Text]
Ruzek, M. C., Miller, A. H., Opal, S. M., Pearce, B. D., Biron, C. A. (1997). Characterization of Early Cytokine Responses and an Interleukin (IL)-6-dependent Pathway of Endogenous Glucocorticoid Induction during Murine Cytomegalovirus Infection. JEM 185: 1185-1192 [Abstract] [Full Text]
Liao, W., Rudling, M., Angelin, B. (1997). Contrasting Effects of Growth Hormone and Insulin-Like Growth Factor I on the Biological Activities of Endotoxin in the Rat. Endocrinology 138: 289-295 [Abstract] [Full Text]
Karres, I., Kremer, J.-P., Steckholzer, U., Kenney, J. S., Ertel, W. (1996). Transforming Growth Factor-{beta}1 Inhibits Synthesis of Cytokines in Endotoxin-Stimulated Human Whole Blood. Arch Surg 131: 1310-1317 [Abstract]
Beutler, B., Munford, R. S. (1996). Tumor Necrosis Factor and the Jarisch-Herxheimer Reaction. NEJM 335: 346-348 [Full Text]
Veloso, D., Denny, S., Cosgriff, T.M., Hochstein, H.D. (1995). Differential susceptibility of rhesus monkeys to high doses of endotoxin. Innate Immunity 2: 411-420 [Abstract]
Tufano, M.A., Catalanotti, P., Capasso, C., De Paolis, P., Ranieri, M., Rossano, F. (1995). Compartmentalization of intravesical and systemic interleukin-6 and tumor necrosis factor {alpha} in mice stimulated with porins and lipopolysaccharide from Salmonella typhimurium. Innate Immunity 2: 359-364 [Abstract]
Boermeester, M. A., van Leeuwen, P. A. M., Coyle, S. M., Wolbink, G. J., Hack, C. E., Lowry, S. F. (1995). Interleukin-1 Blockade Attenuates Mediator Release and Dysregulation of the Hemostatic Mechanism During Human Sepsis. Arch Surg 130: 739-748 [Abstract]
Feuerstein, G.Z., Neville, L.F., Rabinovici, R. (1995). Pulmonary TNF{alpha} is a critical mediator in Adult Respiratory Distress Syndrome. Innate Immunity 2: 189-193 [Abstract]
Abraham, E., Wunderink, R., Silverman, H., Perl, T. M., Nasraway, S., Levy, H., Bone, R., Wenzel, R. P., Balk, R., Allred, R., Pennington, J. E., Wherry, J. C., TNF-{alpha} MAb Sepsis Study Group, , Abraham, E., Bellamy, P., Cryer, H., Busuttil, R., Winston, D., Perry, C., Wunderink, R., Leeper, K. V. Jr, Jones, C., Silverman, H., Martin, M., Tuma, P., Baird, I., Brooks, J., Baird, R., Wenzel, R. P., Perl, T. M., Rangel, S., Wagner, N., Costigan, M., Gutierrez, G., Johnson, P., Clark, C., Grover, C., Gay, P. C., Stekelberg, J., Van Steinburg, P., Nasraway, S., Ortiz, J., Sigel, P., Murphy, A., Lahey, W., Plouffe, J., Fass, R. J., Russell, J., Crowell, R. E., Simpson, S. Q., Neidhart, M., Dunn, M., Saravolatz, L., Griffin, N., Samo, T. C., Feinstein, V., Doyle, K., Tuttle, C., Brown, R., Steingrub, J., Safford, M. J., Bacon, A. III, Holloway, W., Amato, S., Schneider, F., Toews, G. B., Fekety, R. Jr, Kugler, J., Hampton, J., Kahn, F. A., Karnik, A., Niederman, M., Cunha, B., Clare, N., Leatherman, J., Peterson, P. K., Doak, C., Zimmerman, L., Gottlieb, J. E., Stokes, L., Sessler, C., Bone, R., Balk, R., Deere, K., Gloskey, D., Longworth, D., Steingrub, J., Safford, M. J., Liucchi, L., Strange, C., Oser, R., Gilbert, D., Leggett, J. E., Waite, K., Christou, N. V., Magder, S., Bonneau, M., Tan, J. S., File, T., Salstrom, S. J., Eaton, S., Garber, G., Jones, G., Seguin, I., Chow, A. W., Tweeddale, M., Schwartz, L., Pankey, G., Vollenweider, J., Neu, H., Garvey, G., Dorney, P., Jacobs, R. A., Bernstein, M., Octavio, J., Schillinger, B., Iberti, T., Russell, J., Sheagren, J., Craven, D., Poole, L., Myers, W., Ash, M., Czarny, N., Arcieri, G., Koch, G., Prove, J., Remick, D., Fournel, M. (1995). Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor {alpha} in Patients With Sepsis Syndrome: A Randomized, Controlled, Double-blind, Multicenter Clinical Trial. JAMA 273: 934-941 [Abstract]
Cheng, J, Turksen, K, Yu, Q C, Schreiber, H, Teng, M, Fuchs, E (1992). Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.. Genes Dev. 6: 1444-1456 [Abstract]
Leon, P., Redmond, H. P., Shou, J., Daly, J. M. (1992). Interleukin 1 and Its Relationship to Endotoxin Tolerance. Arch Surg 127: 146-151 [Abstract]
Long, C. L., Lowry, S. F. (1990). Hormonal Regulation of Protein Metabolism. JPEN J Parenter Enteral Nutr 14: 555-562
Chesnokova, V., Kariagina, A., Melmed, S. (2002). Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation. Am. J. Physiol. Endocrinol. Metab. 282: E1110-E1118 [Abstract] [Full Text]