Journal of Experimental Medicine, Vol 170, 1463-1468, Copyright © 1989 by Rockefeller University Press

ARTICLES

Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes

EB Smeland, HK Blomhoff, S Funderud, MR Shalaby and T Espevik
Department of Pathology, Institute for Cancer Research, Montebello, Oslo, Norway.

In this paper we have shown that extensively purified human B lymphocytes respond to IL-4 treatment with a marked production of IL-6. Addition of anti-mu potentiated the effect of IL-4 on IL-6 production. Other cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce IL-6 secretion when given to resting B cells. Although B cells generally also produced TNF-alpha and TNF-beta upon stimulation, IL-4 did not induce TNF secretion and seemingly had a specific effect on IL-6 production.
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