Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production

doi:10.1084/jem.170.4.1415

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Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production

E Sonoda, R Matsumoto, Y Hitoshi, T Ishii, M Sugimoto, S Araki, A Tominaga, N Yamaguchi and K Takatsu
Department of Biology, Kumamoto University Medical School, Japan.

Effects of transforming growth factor beta (TGF-beta) on IgA production by LPS-stimulated B cells have been studied. TGF-beta itself could augment polyclonal IgA production in concomitant inhibition of polyclonal IgM and IgG1 production. Furthermore, TGF-beta and IL-5 additively augmented IgA production. TGF-beta exerted its activity early in the culture (by 2 d in a 5-d culture) and IL-5 was required late in the culture. Surface IgA- (sIgA-) B cells responded to TGF-beta for the development of IgA-secreting cells. By contrast, sIgA+ B cells, but not sIgA- B cells, responded to IL-5 for IgA production. These results suggest that TGF-beta has a differential role in the induction of IgA production from IL-5 on murine-activated B cells.
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