Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex

doi:10.1084/jem.170.4.1133

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Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex

T Matsuyama, A Yamada, J Kay, KM Yamada, SK Akiyama, SF Schlossman and C Morimoto
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell- adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Anti4B4(CDw29) antibody blocked the activation of CD4 cells in this system. Furthermore, it is the VLA-5 protein within the set of molecules recognized by anti-4B4 that serves as a fibronectin receptor on the CD4 lymphocytes. The VLA-5 fibronectin receptor was mainly expressed on CD4+ CD45R-CDw29+ cells and may in part contribute to the unique function of these cells.
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Lombardi, G., Burzyn, D., Mundinano, J., Berguer, P., Bekinschtein, P., Costa, H., Castillo, L. F., Goldman, A., Meiss, R., Piazzon, I., Nepomnaschy, I. (2005). Cathepsin-L Influences the Expression of Extracellular Matrix in Lymphoid Organs and Plays a Role in the Regulation of Thymic Output and of Peripheral T Cell Number. J. Immunol. 174: 7022-7032 [Abstract] [Full Text]
Sturm, A., Krivacic, K. A., Fiocchi, C., Levine, A. D. (2004). Dual Function of the Extracellular Matrix: Stimulatory for Cell Cycle Progression of Naive T Cells and Antiapoptotic for Tissue-Derived Memory T Cells. J. Immunol. 173: 3889-3900 [Abstract] [Full Text]
Vivinus-Nebot, M., Rousselle, P., Breittmayer, J.-P., Cenciarini, C., Berrih-Aknin, S., Spong, S., Nokelainen, P., Cottrez, F., Marinkovich, M. P., Bernard, A. (2004). Mature Human Thymocytes Migrate on Laminin-5 with Activation of Metalloproteinase-14 and Cleavage of CD44. J. Immunol. 172: 1397-1406 [Abstract] [Full Text]
Shao, H., Lei, S., Sun, S. L., Xiang, J., Kaplan, H. J., Sun, D. (2003). CpG-Containing Oligodeoxynucleotide 1826 Converts the Weak Uveitogenic Rat Interphotoreceptor Retinoid-Binding Protein Peptide 1181-1191 into a Strong Uveitogen. J. Immunol. 171: 4780-4785 [Abstract] [Full Text]
Puente, L. G., Ostergaard, H. L. (2003). {beta}1/{beta}3 integrin ligation is uncoupled from ERK1/ERK2 activation in cytotoxic T lymphocytes. J. Leukoc. Biol. 73: 391-398 [Abstract] [Full Text]
Nishiya, N., Tachibana, K., Shibanuma, M., Mashimo, J.-i., Nose, K. (2001). Hic-5-Reduced Cell Spreading on Fibronectin: Competitive Effects between Paxillin and Hic-5 through Interaction with Focal Adhesion Kinase. Mol. Cell. Biol. 21: 5332-5345 [Abstract] [Full Text]
Finke, D., Baribaud, F., Diggelmann, H., Acha-Orbea, H. (2001). Extrafollicular Plasmablast B Cells Play a Key Role in Carrying Retroviral Infection to Peripheral Organs. J. Immunol. 166: 6266-6275 [Abstract] [Full Text]
Seiffert, M., Brossart, P., Cant, C., Cella, M., Colonna, M., Brugger, W., Kanz, L., Ullrich, A., Buhring, H.-J. (2001). Signal-regulatory protein {alpha} (SIRP{alpha}) but not SIRP{beta} is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34+CD38{-} hematopoietic cells. Blood 97: 2741-2749 [Abstract] [Full Text]
Miyamoto, Y. J., Wann, E. R., Fowler, T., Duffield, E., Hook, M., McIntyre, B. W. (2001). Fibronectin Binding Protein A of Staphylococcus aureus Can Mediate Human T Lymphocyte Adhesion and Coactivation. J. Immunol. 166: 5129-5138 [Abstract] [Full Text]
Geberhiwot, T, Assefa, D, Kortesmaa, J, Ingerpuu, S, Pedraza, C, Wondimu, Z, Charo, J, Kiessling, R, Virtanen, I, Tryggvason, K, Patarroyo, M (2001). Laminin-8 (alpha4beta1gamma1) is synthesized by lymphoid cells, promotes lymphocyte migration and costimulates T cell proliferation. J. Cell Sci. 114: 423-433 [Abstract]
Rao, W. H., Hales, J. M., Camp, R. D. R. (2000). Potent Costimulation of Effector T Lymphocytes by Human Collagen Type I. J. Immunol. 165: 4935-4940 [Abstract] [Full Text]
Coito, A. J., Onodera, K., Kato, H., Busuttil, R. W., Kupiec-Weglinski, J. W. (2000). Fibronectin-Mononuclear Cell Interactions Regulate Type 1 Helper T Cell Cytokine Network in Tolerant Transplant Recipients. Am. J. Pathol. 157: 1207-1218 [Abstract] [Full Text]
Kokura, S., Wolf, R. E., Yoshikawa, T., Granger, D. N., Aw, T. Y. (2000). Postanoxic T Lymphocyte-Endothelial Cell Interactions Induce Tumor Necrosis Factor-{alpha} Production and Neutrophil Adhesion : Role of Very Late Antigen-4/Vascular Cell Adhesion Molecule-1. Circ. Res. 86: 1237-1244 [Abstract] [Full Text]
Aoudjit, F., Vuori, K. (2000). Engagement of the alpha 2beta 1 integrin inhibits Fas ligand expression and activation-induced cell death in T cells in a focal adhesion kinase-dependent manner. Blood 95: 2044-2051 [Abstract] [Full Text]
Molla, A., Block, M. R. (2000). Adherence of Human Erythroleukemia Cells Inhibits Proliferation without Inducing Differentiation. Cell Growth Differ. 11: 83-90 [Abstract] [Full Text]
Ohashi, Y., Iwata, S., Kamiguchi, K., Morimoto, C. (1999). Tyrosine Phosphorylation of Crk-Associated Substrate Lymphocyte-Type Is a Critical Element in TCR- and {beta}1 Integrin-Induced T Lymphocyte Migration. J. Immunol. 163: 3727-3734 [Abstract] [Full Text]
Kamiguchi, K., Tachibana, K., Iwata, S., Ohashi, Y., Morimoto, C. (1999). Cas-L Is Required for {beta}1 Integrin-Mediated Costimulation in Human T Cells. J. Immunol. 163: 563-568 [Abstract] [Full Text]
Shenoi, H., Seavitt, J., Zheleznyak, A., Thomas, M. L., Brown, E. J. (1999). Regulation of Integrin-Mediated T Cell Adhesion by the Transmembrane Protein Tyrosine Phosphatase CD45. J. Immunol. 162: 7120-7127 [Abstract] [Full Text]
Marshall, W. L., Brinkman, B. M. N., Ambrose, C. M., Pesavento, P. A., Uglialoro, A. M., Teng, E., Finberg, R. W., Browning, J. L., Goldfeld, A. E. (1999). Signaling Through the Lymphotoxin-{beta} Receptor Stimulates HIV-1 Replication Alone and in Cooperation with Soluble or Membrane-Bound TNF-{alpha}. J. Immunol. 162: 6016-6023 [Abstract] [Full Text]
Reinhold, M. I., Green, J. M., Lindberg, F. P., Ticchioni, M., Brown, E. J. (1999). Cell spreading distinguishes the mechanism of augmentation of T cell activation by integrin-associated protein/CD47 and CD28. Int Immunol 11: 707-718 [Abstract] [Full Text]
Kitani, A., Nakashima, N., Izumihara, T., Inagaki, M., Baoui, X., Yu, S., Matsuda, T., Matsuyama, T. (1998). Soluble VCAM-1 Induces Chemotaxis of Jurkat and Synovial Fluid T Cells Bearing High Affinity Very Late Antigen-4. J. Immunol. 161: 4931-4938 [Abstract] [Full Text]
Fujita, H., Kamiguchi, K., Cho, D., Shibanuma, M., Morimoto, C., Tachibana, K. (1998). Interaction of Hic-5, A Senescence-related Protein, with Focal Adhesion Kinase. J. Biol. Chem. 273: 26516-26521 [Abstract] [Full Text]
Woodside, D. G., Wooten, D. K., McIntyre, B. W. (1998). Adenosine Diphosphate (ADP)-Ribosylation of the Guanosine Triphosphatase (GTPase) Rho in Resting Peripheral Blood Human T Lymphocytes Results in Pseudopodial Extension and the Inhibition of T Cell Activation. JEM 188: 1211-1221 [Abstract] [Full Text]
Borron, P., McCormack, F. X., Elhalwagi, B. M., Chroneos, Z. C., Lewis, J. F., Zhu, S., Wright, J. R., Shepherd, V. L., Possmayer, F., Inchley, K., Fraher, L. J. (1998). Surfactant protein A inhibits T cell proliferation via its collagen-like tail and a 210-kDa receptor. Am. J. Physiol. Lung Cell. Mol. Physiol. 275: L679-L686 [Abstract] [Full Text]
Sato, T., Ohashi, Y., Tachibana, K., Soiffer, R. J., Ritz, J., Morimoto, C. (1997). Altered Tyrosine Phosphorylation Via the Very Late Antigen (VLA)/beta 1 Integrin Stimulation Is Associated With Impaired T-Cell Signaling Through VLA-4 After Allogeneic Bone Marrow Transplantation. Blood 90: 4222-4229 [Abstract] [Full Text]
Tachibana, K., Urano, T., Fujita, H., Ohashi, Y., Kamiguchi, K., Iwata, S., Hirai, H., Morimoto, C. (1997). Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase. A PUTATIVE MECHANISM FOR THE INTEGRIN-MEDIATED TYROSINE PHOSPHORYLATION OF Crk-ASSOCIATED SUBSTRATES. J. Biol. Chem. 272: 29083-29090 [Abstract] [Full Text]
Bahr, B. A., Staubli, U., Xiao, P., Chun, D., Ji, Z.-X., Esteban, E. T., Lynch, G. (1997). Arg-Gly-Asp-Ser-Selective Adhesion and the Stabilization of Long-Term Potentiation: Pharmacological Studies and the Characterization of a Candidate Matrix Receptor. J. Neurosci. 17: 1320-1329 [Abstract] [Full Text]
Manie, S. N., Beck, A. R.P., Astier, A., Law, SusanF., Canty, T., Hirai, H., Druker, B. J., Avraham, H., Haghayeghi, N., Sattler, M., Salgia, R., Griffin, JamesD., Golemis, EricaA., Freedman, A. S. (1997). Involvement of p130Cas and p105HEF1, a Novel Cas-like Docking Protein, in a Cytoskeleton-dependent Signaling Pathway Initiated by Ligation of Integrin or Antigen Receptor on Human B Cells. J. Biol. Chem. 272: 4230-4236 [Abstract] [Full Text]
Reinhold, M. I., Lindberg, F. P., Kersh, G. J., Allen, P. M., Brown, E. J. (1997). Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway. JEM 185: 1-12 [Abstract] [Full Text]
Pallis, M., Lim, K., Gardner-Medwin, J., Robins, R., Powell, R. (1997). Correlation between CD29 density on CD8 + lymphocytes and serum IgG in systemic lupus erythematosus. Lupus 6: 379-384 [Abstract]
Udagawa, T., McIntyre, B. W. (1996). ADP-ribosylation of the G Protein Rho Inhibits Integrin Regulation of Tumor Cell Growth. J. Biol. Chem. 271: 12542-12548 [Abstract] [Full Text]
Wilkins, J. A., Li, A., Ni, H., Stupack, D. G., Shen, C. (1996). Control of beta(1) Integrin Function. J. Biol. Chem. 271: 3046-3051 [Abstract] [Full Text]
Hunt, S. W. III, Harris, E. S., Kellermann, S.-A., Shimizu, Y. (1996). T-Lymphocyte Interactions With Endothelium and Extracellular Matrix. CROBM 7: 59-86 [Abstract] [Full Text]
Berditchevski, F., Bazzoni, G., Hemler, M. E. (1995). Specific Association Of CD63 with the VLA-3 and VLA-6 Integrins. J. Biol. Chem. 270: 17784-17790 [Abstract] [Full Text]
Yoshimura, M., Nishikawa, A., Nishiura, T., Ihara, Y., Kanayama, Y., Matsuzawa, Y., Taniguchi, N. (1995). Cell Spreading in Colo 201 by Staurosporin Is alpha3beta1 Integrin-mediated with Tyrosine Phosphorylation of Src and Tensin. J. Biol. Chem. 270: 2298-2304 [Abstract] [Full Text]
Symington, B., Carter, W. (1995). Modulation of epidermal differentiation by epiligrin and integrin alpha 3 beta 1. J. Cell Sci. 108: 831-838 [Abstract]
Schwartz, R. (1990). A cell culture model for T lymphocyte clonal anergy. Science 248: 1349-1356 [Abstract]