Journal of Experimental Medicine, Vol 170, 1059-1073, Copyright © 1989 by Rockefeller University Press

ARTICLES

Analysis of Mlsc genetics. A novel instance of genetic redundancy

R Abe, M Foo-Phillips and RJ Hodes
Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892.

The identity of the self determinants involved in the selection of the T cell repertoire has been a matter of considerable interest. In addition to the apparent critical role of MHC gene products, accumulated experimental results indicate the importance of non-MHC gene products in T cell repertoire selection. In particular, murine Mlsa and Mlsc determinants have been shown to be highly stimulatory to allogeneic T cells and to be involved in the negative selection (elimination) of self-reactive T cells expressing selected TCR V beta segments. In this work, a unique phenomenon of genetic redundancy is described in the control of Mlsc expression: Mlsc appears to be controlled by at least two unlinked loci, and the product of either one of these loci is sufficient to evoke Mlsc-specific T cell response and to act as a ligand in the deletion of self Mlsc-reactive V beta 3+ T cells. Based on these findings, we propose a possible explanation for the fact that Mls-like genes or gene products have not been identified in other species such as man.
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This article has been cited by other articles:

• Pantaleo, G., Graziosi, C., Fauci, A. S. (1993). The Immunopathogenesis of Human Immunodeficiency Virus Infection. NEJM 328: 327-335 [Full Text]  
• Woodland, D, Happ, M., Bill, J, Palmer, E (1990). Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells. Science 247: 964-967 [Abstract]  

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