Journal of Experimental Medicine, Vol 170, 1027-1032, Copyright © 1989 by Rockefeller University Press

ARTICLES

Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series

J Gorski, C Irle, EM Mickelson, MJ Sheehy, A Termijtelen, C Ucla and B Mach
Department of Microbiology, University of Geneva Medical School, Switzerland.

A third allele at the DRB3 locus, DRw52c, represents an intermediate sequence between DRw52a and DRw52b and may have arisen by a gene conversion-like event. The recognition of cells bearing these molecules by a number of alloreactive and antigen-specific DR-restricted T cell clones was analyzed. On the basis of a theoretical model of HLA class II structure, distinct amino acid clusters have been identified as motifs controlling TCR recognition. These are located both in the cleft and in the alpha-helical edge of the MHC class II recognition platform. Motifs shared between two alleles may restrict public T cell clones.
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This article has been cited by other articles:

• Dai, S., Crawford, F., Marrack, P., Kappler, J. W. (2008). The structure of HLA-DR52c: Comparison to other HLA-DRB3 alleles. Proc. Natl. Acad. Sci. USA 105: 11893-11897 [Abstract] [Full Text]  
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