Journal of Experimental Medicine, Vol 170, 1009-1014, Copyright © 1989 by Rockefeller University Press

ARTICLES

Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells

P Aparicio, JM Alonso, ML Toribio, MA Marcos, L Pezzi and C Martinez-A
Centro de Biologia Molecular, C.S.I.C., Universidad Autonoma, Madrid, Spain.

Lymphocytes isolated from human fetal liver and expanded in vitro in IL- 2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse targets in lectin-mediated killing assays and to perform classical helper functions. These results add new information necessary for a better understanding of the physiological role of the gamma, delta T cells.
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This article has been cited by other articles:

• Sinkora, M., Sinkorova, J., Cimburek, Z., Holtmeier, W. (2007). Two Groups of Porcine TCR{gamma}{delta}+ Thymocytes Behave and Diverge Differently. J. Immunol. 178: 711-719 [Abstract] [Full Text]  
• Carding, S R, Kyes, S, Jenkinson, E J, Kingston, R, Bottomly, K, Owen, J J, Hayday, A C (1990). Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.. Genes Dev. 4: 1304-1315 [Abstract]  

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