Murine V kappa gene expression does not follow the VH paradigm

doi:10.1084/jem.169.5.1859

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Murine V kappa gene expression does not follow the VH paradigm

A Kaushik, DH Schulze, C Bona and G Kelsoe
Department of Microbiology, Mount Sinai School of Medicine, New York 10029.

V kappa gene family expression among LPS-reactive murine B lymphocytes, unlike that of VH gene families, is not proportional to genomic complexity, i.e., nonstoichiometric. Furthermore, no positional bias for the overexpression of J-proximal V kappa genes (V kappa 21) is observed among neonatal B lymphocytes. Yet, the V kappa 1 and V kappa 9 families located in the center of V kappa locus are preferentially used by neonatal B splenocytes. Thus, the mechanisms of V kappa gene rearrangement and expression appear to differ significantly from those controlling the VH locus.
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