A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

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A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

S Yonehara, A Ishii and M Yonehara
Department of Cell Biology, Tokyo Metropolitan Institute of Medical Science, Japan.

We have prepared an mAb specific for a human cell surface component (termed anti-Fas mAb). Anti-Fas shows cell-killing activity that is indistinguishable from the cytolytic activity of TNF. Fas antigen was characterized by western blotting, indicating that Fas antigen is a cell surface protein with a molecular weight of 200,000, which is different from the molecular weight of TNF-R. Fas antigen, however, is co-downregulated with the TNF-R when cells sensitive to the cytolytic activity of TNF are incubated with either TNF or anti-Fas. In contrast, Fas antigen on cells insensitive to TNF is not co-downregulated with the TNF-R. We suggest that the cell-killing activity of TNF is mediated by Fas antigen associated with the TNF-R.
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Jenkins, M., Keir, M., McCune, J. M. (1999). Fas Is Expressed Early in Human Thymocyte Development But Does Not Transmit an Apoptotic Signal. J. Immunol. 163: 1195-1204 [Abstract] [Full Text]
Hashimoto, W., Osaki, T., Okamura, H., Robbins, P. D., Kurimoto, M., Nagata, S., Lotze, M. T., Tahara, H. (1999). Differential Antitumor Effects of Administration of Recombinant IL-18 or Recombinant IL-12 Are Mediated Primarily by Fas-Fas Ligand- and Perforin-Induced Tumor Apoptosis, Respectively. J. Immunol. 163: 583-589 [Abstract] [Full Text]
Kakinuma, C., Takagaki, K., Yatomi, T., Nakamura, N., Nagata, S., Uemura, A., Shibutani, Y. (1999). Acute Toxicity of an Anti-Fas Antibody in Mice. Toxicol Pathol 27: 412-420 [Abstract]
Pan, G., Vickers, S. M., Pickens, A., Phillips, J. O., Ying, W., Thompson, J. A., Siegal, G. P., McDonald, J. M. (1999). Apoptosis and Tumorigenesis in Human Cholangiocarcinoma Cells : Involvement of Fas/APO-1 (CD95) and Calmodulin. Am. J. Pathol. 155: 193-203 [Abstract] [Full Text]
Shimizu, M., Fontana, A., Takeda, Y., Yagita, H., Yoshimoto, T., Matsuzawa, A. (1999). Induction of Antitumor Immunity with Fas/APO-1 Ligand (CD95L)-Transfected Neuroblastoma Neuro-2a Cells. J. Immunol. 162: 7350-7357 [Abstract] [Full Text]
Shin, M. S., Park, W. S., Kim, S. Y., Kim, H. S., Kang, S. J., Song, K. Y., Park, J. Y., Dong, S. M., Pi, J. H., Oh, R. R., Lee, J. Y., Yoo, N. J., Lee, S. H. (1999). Alterations of Fas (Apo-1/CD95) Gene in Cutaneous Malignant Melanoma. Am. J. Pathol. 154: 1785-1791 [Abstract] [Full Text]
Kottke, T. J., Blajeski, A. L., Martins, L. M., Mesner, P. W. Jr., Davidson, N. E., Earnshaw, W. C., Armstrong, D. K., Kaufmann, S. H. (1999). Comparison of Paclitaxel-, 5-Fluoro-2'-deoxyuridine-, and Epidermal Growth Factor (EGF)-induced Apoptosis. EVIDENCE FOR EGF-INDUCED ANOIKIS. J. Biol. Chem. 274: 15927-15936 [Abstract] [Full Text]
Suzuki, A., Tsutomi, Y., Yamamoto, N., Shibutani, T., Akahane, K. (1999). Mitochondrial Regulation of Cell Death: Mitochondria Are Essential for Procaspase 3-p21 Complex Formation To Resist Fas-Mediated Cell Death. Mol. Cell. Biol. 19: 3842-3847 [Abstract] [Full Text]
Kim, J.-M., Yoon, Y.-D., Tsang, B. K. (1999). Involvement of the Fas/Fas Ligand System in p53-Mediated Granulosa Cell Apoptosis during Follicular Development and Atresia. Endocrinology 140: 2307-2317 [Abstract] [Full Text]
SCHETT, G., STEINER, C.-W., GRÖGER, M., WINKLER, S., GRANINGER, W., SMOLEN, J., XU, Q., STEINER, G. (1999). Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 13: 833-842 [Abstract] [Full Text]
Izban, K. F., Wrone-Smith, T., Hsi, E. D., Schnitzer, B., Quevedo, M. E., Alkan, S. (1999). Characterization of the Interleukin-1�-Converting Enzyme/Ced-3-Family Protease, Caspase-3/CPP32, in Hodgkin's Disease : Lack of Caspase-3 Expression in Nodular Lymphocyte Predominance Hodgkin's Disease. Am. J. Pathol. 154: 1439-1447 [Abstract] [Full Text]
Courtney, P A, Crockard, A D, Williamson, K, Irvine, A E, Kennedy, R J, Bell, A L (1999). Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia. Ann Rheum Dis 58: 309-314 [Abstract] [Full Text]
Payne, S. G., Smith, S. C., Davidge, S. T., Baker, P. N., Guilbert, L. J. (1999). Death Receptor Fas/Apo-1/CD95 Expressed by Human Placental Cytotrophoblasts Does Not Mediate Apoptosis. Biol. Reprod. 60: 1144-1150 [Abstract] [Full Text]
Roughton, S. A., Lareu, R. R., Bittles, A. H., Dharmarajan, A. M. (1999). Fas and Fas Ligand Messenger Ribonucleic Acid and Protein Expression in the Rat Corpus Luteum during Apoptosis-Mediated Luteolysis. Biol. Reprod. 60: 797-804 [Abstract] [Full Text]