Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain

doi:10.1084/jem.169.5.1557

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Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain

A Wright, JE Lee, MP Link, SD Smith, W Carroll, R Levy, C Clayberger and AM Krensky
Department of Pediatrics, Stanford University School of Medicine, California 94305.

CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.
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