The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
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Journal of Experimental Medicine, Vol 169, 987-993, Copyright © 1989 by Rockefeller University Press

ARTICLES

Interferon alpha associated with systemic lupus erythematosus is not intrinsically acid labile

AM Yee, JP Buyon and YK Yip
Department of Microbiology, Sackler Institute of Graduate Biomedical Sciences, New York, New York.

The physicochemical properties of apparently acid-labile IFN-alpha from patients with SLE have been studied. The antigenicity, apparent molecular size, and isoelectric point of SLE IFN-alpha are indistinguishable from those of conventional, previously characterized, acid-stable subspecies of IFN-alpha. However, after partial purification by anion-exchange chromatography, SLE IFN-alpha no longer exhibits acid lability, suggesting that other plasma factor(s) are responsible for the acid lability of SLE IFN-alpha. Addition of SLE plasma, but not normal plasma, to conventional acid-stable IFN-alpha renders the exogenous IFN-alpha acid labile. Preliminary results demonstrate that an acid-dependent IFN-inactivating activity can be partially purified from SLE plasma by anion-exchange chromatography.
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