The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 169, 953-972, Copyright © 1989 by Rockefeller University Press

ARTICLES

Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression

DM Nanus, SA Ebrahim, NH Bander, FX Real, LM Pfeffer, JR Shapiro and AP Albino
Memorial Sloan-Kettering Cancer Center, New York, New York.

Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These include changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor production, and chromosomal stability. Further, there are spontaneous progressive alterations in vitro in the karyotype and antigenic profile of the transformed cells. Cytogenetic analyses suggest that alterations of chromosome 21 may play an early and pivotal role in the development of transformed proximal tubule cells.
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