Journal of Experimental Medicine, Vol 169, 585-590, Copyright © 1989 by Rockefeller University Press

ARTICLES

A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97

KS Furukawa, K Furukawa, FX Real, LJ Old and KO Lloyd
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

Analysis of antibodies present in the serum of melanoma patient FD has shown that they detect a unique tumor epitope present only on the autologous melanoma cell line SK-MEL-131. Previous results had shown that the unique FD epitope is carried on a common glycoprotein of approximately 90 kD, widely expressed on melanoma and a few other cell types. We now show by sequential radioimmunoprecipitation and partial amino acid sequencing that this common molecule is a previously recognized melanoma antigen, originally identified by mouse mAbs, designated gp95 or p97 (and also known as melanotransferrin). Thus, FD is the first of the class I (unique) melanoma antigens that has been characterized and related to a known cell surface molecule.
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This article has been cited by other articles:

• Noronha, E. J., Wang, X., Desai, S. A., Kageshita, T., Ferrone, S. (1998). Limited Diversity of Human scFv Fragments Isolated by Panning a Synthetic Phage-Display scFv Library with Cultured Human Melanoma Cells. J. Immunol. 161: 2968-2976 [Abstract] [Full Text]  
• Alemany, R, Vila, M., Franci, C, Egea, G, Real, F., Thomson, T. (1993). Glycosyl phosphatidylinositol membrane anchoring of melanotransferrin (p97): apical compartmentalization in intestinal epithelial cells. J. Cell Sci. 104: 1155-1162 [Abstract]  

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