Chromosomal organization of the human major histocompatibility complex class I gene family [published erratum appears in J Exp Med 1989 Apr 1;169(4):1517]

doi:10.1084/jem.169.2.469

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Chromosomal organization of the human major histocompatibility complex class I gene family [published erratum appears in J Exp Med 1989 Apr 1;169(4):1517]

BH Koller, DE Geraghty, R DeMars, L Duvick, SS Rich and HT Orr
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.

17 HLA class I genes have been isolated from the genome of B- lymphoblastoid cell line 721. Sequence analysis and transfection studies indicate that three genes, in addition to those encoding the HLA-A, -B, and -C antigens can direct the synthesis of a class I alpha protein (4, 5, 21). Using gene-specific DNA probes to analyze the presence of restriction fragment-length polymorphisms within a large pedigree and in panel of HLA deletion mutant cell lines, we show here that two of these genes, designated HLA-G and HLA-F, are located on the short arm of chromosome 6 telomeric to the HLA-A locus. The third expressed non-A, -B, and -C class I gene, HLA-E, is located between HLA- A and HLA-C (4). In addition, the remaining 11 class I pseudogenes and gene fragments are localized relative to established markers on chromosome 6p.
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