Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)

doi:10.1084/jem.169.1.363

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Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)

J Van Snick, A Goethals, JC Renauld, E Van Roost, C Uyttenhove, MR Rubira, RL Moritz and RJ Simpson
Ludwig Institute for Cancer Research, Brussels, Belgium.

Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the cloning and expression of a cDNA for this new growth factor. The predicted mature protein is a cationic cysteine-rich polypeptide of 14 kD without significant homology to previously sequenced proteins.
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