Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells

doi:10.1084/jem.168.6.2385

This Article

	Full Text (PDF, 439K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Rothman, P.
	Articles by Alt, F. W.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Rothman, P.
	Articles by Alt, F. W.


Social Bookmarking

	What's this?

ARTICLES

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells

P Rothman, S Lutzker, W Cook, R Coffman and FW Alt
Howard Hughes Medical Institute, New York, New York.

To elucidate the mechanism of IL-4-induced enhancement of IgE and IgG1 production, murine splenic B cells and A-MuLV-transformed cells were cultured with LPS and IL-4 and assayed for epsilon and gamma 1 transcripts. Concomitant treatment with IL-4 and LPS induced expression of C epsilon transcripts in both normal and transformed cells. Expression of these truncated C epsilon transcripts preceded accumulation of normal epsilon mRNA in treated cells. Consistent data were obtained with respect to gamma 1 RNA expression. These results suggest that IL-4 can direct class switching in the context of a mechanism associated with differential expression of germline constant region genes.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Stavnezer, J., Kang, J. (2009). The Surprising Discovery That TGF{beta} Specifically Induces the IgA Class Switch. J. Immunol. 182: 5-7 [Full Text]
Fransen, F., Boog, C. J., van Putten, J. P., van der Ley, P. (2007). Agonists of Toll-Like Receptors 3, 4, 7, and 9 Are Candidates for Use as Adjuvants in an Outer Membrane Vaccine against Neisseria meningitidis Serogroup B. Infect. Immun. 75: 5939-5946 [Abstract] [Full Text]
Casola, S., Cattoretti, G., Uyttersprot, N., Koralov, S. B., Segal, J., Hao, Z., Waisman, A., Egert, A., Ghitza, D., Rajewsky, K. (2006). Tracking germinal center B cells expressing germ-line immunoglobulin {gamma}1 transcripts by conditional gene targeting. Proc. Natl. Acad. Sci. USA 103: 7396-7401 [Abstract] [Full Text]
Fear, D. J., McCloskey, N., O'Connor, B., Felsenfeld, G., Gould, H. J. (2004). Transcription of Ig Germline Genes in Single Human B Cells and the Role of Cytokines in Isotype Determination. J. Immunol. 173: 4529-4538 [Abstract] [Full Text]
Wang, C. L., Wabl, M. (2004). DNA Acrobats of the Ig Class Switch. J. Immunol. 172: 5815-5821 [Abstract] [Full Text]
Dainichi, T., Maekawa, Y., Ishii, K., Zhang, T., Nashed, B. F., Sakai, T., Takashima, M., Himeno, K. (2001). Nippocystatin, a Cysteine Protease Inhibitor from Nippostrongylus brasiliensis, Inhibits Antigen Processing and Modulates Antigen-Specific Immune Response. Infect. Immun. 69: 7380-7386 [Abstract] [Full Text]
Horikawa, K., Kaku, H., Nakajima, H., Davey, H. W., Henninghausen, L., Iwamoto, I., Yasue, T., Kariyone, A., Takatsu, K. (2001). Essential Role of Stat5 for IL-5-Dependent IgH Switch Recombination in Mouse B Cells. J. Immunol. 167: 5018-5026 [Abstract] [Full Text]
Mao, C.-s., Stavnezer, J. (2001). Differential Regulation of Mouse Germline Ig {gamma}1 and {epsilon} Promoters by IL-4 and CD40. J. Immunol. 167: 1522-1534 [Abstract] [Full Text]
Shen, C.-H., Stavnezer, J. (2001). Activation of the Mouse Ig Germline {{epsilon}} Promoter by IL-4 Is Dependent on AP-1 Transcription Factors. J. Immunol. 166: 411-423 [Abstract] [Full Text]
Ehigiator, H. N., Stadnyk, A. W., Lee, T. D. G. (2000). Extract of Nippostrongylus brasiliensis Stimulates Polyclonal Type-2 Immunoglobulin Response by Inducing De Novo Class Switch. Infect. Immun. 68: 4913-4922 [Abstract] [Full Text]
Coyle, J. H., Lebman, D. A. (2000). Correct Immunoglobulin {alpha} mRNA Processing Depends on Specific Sequence in the C{alpha}3-{alpha}M Intron. J. Immunol. 164: 3659-3665 [Abstract] [Full Text]
Muller-Ladner, U., Judex, M., Ballhorn, W., Kullmann, F., Distler, O., Schlottmann, K., Gay, R. E., Scholmerich, J., Gay, S. (2000). Activation of the IL-4 STAT Pathway in Rheumatoid Synovium. J. Immunol. 164: 3894-3901 [Abstract] [Full Text]
Harris, M. B., Chang, C.-C., Berton, M. T., Danial, N. N., Zhang, J., Kuehner, D., Ye, B. H., Kvatyuk, M., Pandolfi, P. P., Cattoretti, G., Dalla-Favera, R., Rothman, P. B. (1999). Transcriptional Repression of Stat6-Dependent Interleukin-4-Induced Genes by BCL-6: Specific Regulation of Ivarepsilon Transcription and Immunoglobulin E Switching. Mol. Cell. Biol. 19: 7264-7275 [Abstract] [Full Text]
Bonifacio, E., Scirpoli, M., Kredel, K., Fuchtenbusch, M., Ziegler, A.-G. (1999). Early Autoantibody Responses in Prediabetes Are IgG1 Dominated and Suggest Antigen-Specific Regulation. J. Immunol. 163: 525-532 [Abstract] [Full Text]
Petry, K., Siebenkotten, G., Christine, R., Hein, K., Radbruch, A. (1999). An extrachromosomal switch recombination substrate reveals kinetics and substrate requirements of switch recombination in primary murine B cells. Int Immunol 11: 753-763 [Abstract] [Full Text]
Sherman, M. A., Secor, V. H., Brown, M. A. (1999). IL-4 Preferentially Activates a Novel STAT6 Isoform in Mast Cells. J. Immunol. 162: 2703-2708 [Abstract] [Full Text]
Mizoguchi, C., Uehara, S., Akira, S., Takatsu, K. (1999). IL-5 Induces IgG1 Isotype Switch Recombination in Mouse CD38-Activated sIgD-Positive B Lymphocytes. J. Immunol. 162: 2812-2819 [Abstract] [Full Text]
Schwarze, J., Cieslewicz, G., Hamelmann, E., Joetham, A., Shultz, L. D., Lamers, M. C., Gelfand, E. W. (1999). IL-5 and Eosinophils Are Essential for the Development of Airway Hyperresponsiveness Following Acute Respiratory Syncytial Virus Infection. J. Immunol. 162: 2997-3004 [Abstract] [Full Text]
Imani, F., Proud, D., Griffin, D. E. (1999). Measles Virus Infection Synergizes with IL-4 in IgE Class Switching. J. Immunol. 162: 1597-1602 [Abstract] [Full Text]
Qiu, G., Stavnezer, J. (1998). Overexpression of BSAP/Pax-5 Inhibits Switching to IgA and Enhances Switching to IgE in the I.29{micro} B Cell Line. J. Immunol. 161: 2906-2918 [Abstract] [Full Text]
Linehan, L. A., Warren, W. D., Thompson, P. A., Grusby, M. J., Berton, M. T. (1998). STAT6 Is Required for IL-4-Induced Germline Ig Gene Transcription and Switch Recombination. J. Immunol. 161: 302-310 [Abstract] [Full Text]
Muller, J. R., Marcu, K. B. (1998). Stimulation of Murine B Lymphocytes Induces a DNA Exonuclease Whose Activity on Switch-{micro} DNA Is Specifically Inhibited by Other Germ-Line Switch Region RNAs. J. Immunol. 160: 3337-3341 [Abstract] [Full Text]
Rager, K. J., Langland, J. O., Jacobs, B. L., Proud, D., Marsh, D. G., Imani, F. (1998). Activation of Antiviral Protein Kinase Leads to Immunoglobulin E Class Switching in Human B Cells. J. Virol. 72: 1171-1176 [Abstract] [Full Text]
Davis, H. L., Weeranta, R., Waldschmidt, T. J., Tygrett, L., Schorr, J., Krieg, A. M. (1998). CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen. J. Immunol. 160: 870-876 [Abstract] [Full Text]
Pernis, A., Gupta, S., Yopp, J., Garfein, E., Kashleva, H., Schindler, C., Rothman, P. (1995). [IMAGE]Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors. J. Biol. Chem. 270: 14517-14522 [Abstract] [Full Text]
Hou, J, Schindler, U, Henzel, W., Ho, T., Brasseur, M, McKnight, S. (1994). An interleukin-4-induced transcription factor: IL-4 Stat. Science 265: 1701-1706 [Abstract]
Jung, S, Rajewsky, K, Radbruch, A (1993). Shutdown of class switch recombination by deletion of a switch region control element. Science 259: 984-987 [Abstract]
Kuhn, R, Rajewsky, K, Muller, W (1991). Generation and analysis of interleukin-4 deficient mice. Science 254: 707-710 [Abstract]
Shimizu, A., Kinashi, T., Nussenzweig, M.C., Mizuta, T.-R., Leder, P., Honjo, T. (1989). Molecular Mechanism for Immunoglobulin Double-isotype Expression. Cold Spring Harb Symp Quant Biol 54: 175-181 [Abstract]