Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma

doi:10.1084/jem.168.6.2183

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Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma

Y Kawakami, SA Rosenberg and MT Lotze
Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892.

Addition of IL-4 (1,000 U/ml) to either high or low concentrations of IL-2 augmented tumor-infiltrating lymphocytes (TIL) growth from human melanoma. Weekly restimulation with irradiated tumor cells in conjunction with IL-4 allowed enhanced growth of TIL. With low-dose IL- 2 (10 U/ml) and IL-4, expanded TIL had little cytolytic activity against Daudi or allogeneic tumors. Further, IL-4 augmented the total lytic activity against autologous tumors in most cases. With high-dose IL-2 (1,000 U/ml), IL-4 addition decreased nonspecific killing activity against Daudi or allogeneic melanomas in many cases, and reciprocally augmented cytolytic activity against the autologous melanoma in many cases. This suggests the possible use of IL-4 in cancer therapy, especially in adoptive cellular immunotherapy using TIL or in conjunction with IL-2 administration.
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Clay, T. M., Custer, M. C., Sachs, J., Hwu, P., Rosenberg, S. A., Nishimura, M. I. (1999). Efficient Transfer of a Tumor Antigen-Reactive TCR to Human Peripheral Blood Lymphocytes Confers Anti-Tumor Reactivity. J. Immunol. 163: 507-513 [Abstract] [Full Text]
Kawakami, Y., Robbins, P. F., Wang, X., Tupesis, J. P., Parkhurst, M. R., Kang, X., Sakaguchi, K., Appella, E., Rosenberg, S. A. (1998). Identification of New Melanoma Epitopes on Melanosomal Proteins Recognized by Tumor Infiltrating T Lymphocytes Restricted by HLA-A1, -A2, and -A3 Alleles. J. Immunol. 161: 6985-6992 [Abstract] [Full Text]
Stotter, H., Lotze, M. T. (1991). Human Lymphokine-Activated Killer Cell Activity: Role of IL-2, IL-4, and IL-7. Arch Surg 126: 1525-1530 [Abstract]
Barbolt, T. A., Gossett, K. A., Cornacoff, J. B. (1991). Histomorphologic Observations for Cynomolgus Monkeys after Subchronic Subcutaneous Injection of Recombinant Human Interleukin-4. Toxicol Pathol 19: 251-257 [Abstract]
Balch, C. M., Riley, L. B., Bae, Y. J., Salmeron, M. A., Platsoucas, C. D., von Eschenbach, A., Itoh, K. (1990). Patterns of Human Tumor-Infiltrating Lymphocytes in 120 Human Cancers. Arch Surg 125: 200-205 [Abstract]