The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 168, 2023-2030, Copyright © 1988 by Rockefeller University Press

ARTICLES

Strain variation in the frequency of Abelson murine leukemia virus- transformed fetal liver pre-B cells bearing complete immunoglobulin heavy chain rearrangements

GE Osman, HH Wortis and PH Brodeur
Immunology Program, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts.

Fetal liver Abelson pre-B cell lines obtained from CBA/Tufts.xid and (CBA/Tufts.xid x CBA/Tufts)F1 mice have complete VDJH rearrangements on at least one allele. Such high frequencies of VDJH rearrangements have previously been observed in adult derived but not fetal liver derived Abelson pre-B cell lines. Genetic analyses suggest that CBA/Tufts.xid carries an autosomal dominant gene(s) that determines the predominance of VDJH rearrangements among transformants. This autosomal gene(s) might affect the intrinsic development of the early B cell lineage in the fetus or the fetal microenvironment, expanding pre-B cells of the "more mature" VDJH phenotype.
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