The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 168, 1481-1486, Copyright © 1988 by Rockefeller University Press

ARTICLES

Structure of the gamma/delta T cell receptor of a human thymocyte clone

A Okada, I Bank, L Rogozinski, Y Takihara, TW Mak, L Chess and FW Alt
Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032.

The CD3+, IL-2-dependent normal human thymocyte clone, CII, expresses on its surface a CD3-associated gamma/delta TCR. We have further elucidated the structure of this receptor from the nucleotide sequence of cDNA and genomic clones from CII that encode functional TCR-gamma and -delta chains. We find that the CII line expresses a C gamma 2 constant region that is a polymorphic form lacking a copy of an internal exon; the sequence of this constant region accounts for the size of the gamma chain and noncovalent linkage of gamma and delta chains in the CII TCR. The V gamma region used for the CII TCR is identical to the several previously characterized expressed human V gamma segments. Possible implications of this finding are discussed.
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