Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase

doi:10.1084/jem.168.4.1247

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Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase

M Letarte, S Vera, R Tran, JB Addis, RJ Onizuka, EJ Quackenbush, CV Jongeneel and RR McInnes
Department of Immunology, Hospital for Sick Children, Toronto, Canada.

We purified CALLA from human kidney and isolated a cDNA clone reactive with two oligonucleotide probes corresponding to two distinct peptides. The amino acid sequence translated from the CALLA cDNA revealed 100% identity with that of human neutral endopeptidase (NEP, enkephalinase). The distribution of CALLA antigen and NEP in normal tissues are similar.
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