The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 168, 783-788, Copyright © 1988 by Rockefeller University Press

ARTICLES

Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice

TJ Santoro, DH Morris, RC Murphy and RC Baker
Department of Medicine, University of Colorado Health Sciences Center, Denver.

Eicosanoids have been implicated in the pathogenesis of autoimmune diseases. In this study, peritoneal macrophages from autoimmune-prone mice were examined for their capacity to produce proinflammatory 5- lipoxygenase metabolites. The results indicate that enhanced production of leukotriene C4 is a common feature of murine autoimmunity and suggest further that aberrations in 5-lipoxygenase activity may play a role in the development of lupus.
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