CD4+ T cells are required for development of a murine retrovirus- induced immunodeficiency syndrome (MAIDS)

doi:10.1084/jem.168.2.623

This Article

	Full Text (PDF, 959K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Yetter, R. A.
	Articles by Morse, H. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Yetter, R. A.
	Articles by Morse, H. C., 3d

Social Bookmarking

	What's this?

ARTICLES

CD4+ T cells are required for development of a murine retrovirus- induced immunodeficiency syndrome (MAIDS)

RA Yetter, RM Buller, JS Lee, KL Elkins, DE Mosier, TN Fredrickson and HC Morse 3d
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

Mice depleted in vivo of CD4+ Th cells by treatment with mAb GK1.5 were found to be resistant to the lymphoproliferative/immunodeficiency disease (MAIDS) induced in intact mice by infection with the mixture of LP-BM5 murine leukemia viruses. Depleted mice did not develop lymphadenopathy or splenomegaly, had normal serum IgM levels, normal CTL responses to alloantigens, and were able to generate PFC responses to Th-independent antigens even though frequencies of virus-producing spleen cells were comparable in depleted and intact mice. Depletion of CD4+ Th cells after infection resulted in a reversal of many abnormalities exhibited by infected controls; spleen weights, serum IgM levels, and allogeneic CTL responses of treated mice were comparable to those of uninfected controls. These results demonstrate that dysfunction of CD4+ Th cells is central to the induction and progression of both T and B cell abnormalities in MAIDS.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Green, K. A., Okazaki, T., Honjo, T., Cook, W. J., Green, W. R. (2008). The Programmed Death-1 and Interleukin-10 Pathways Play a Down-Modulatory Role in LP-BM5 Retrovirus-Induced Murine Immunodeficiency Syndrome. J. Virol. 82: 2456-2469 [Abstract] [Full Text]
Li, W., Green, W. R. (2006). The Role of CD4 T Cells in the Pathogenesis of Murine AIDS.. J. Virol. 80: 5777-5789 [Abstract] [Full Text]
Doerre, S., Mesires, K. P., Daley, K. M., McCarty, T., Knoetig, S., Corley, R. B. (2005). Reductions in I{kappa}B{epsilon} and Changes in NF-{kappa}B Activity during B Lymphocyte Differentiation. J. Immunol. 174: 983-991 [Abstract] [Full Text]
Green, K. A., Ahonen, C. L., Cook, W. J., Green, W. R. (2004). CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency. J. Virol. 78: 6055-6060 [Abstract] [Full Text]
Beilharz, M. W., Sammels, L. M., Paun, A., Shaw, K., van Eeden, P., Watson, M. W., Ashdown, M. L. (2004). Timed Ablation of Regulatory CD4+ T Cells Can Prevent Murine AIDS Progression. J. Immunol. 172: 4917-4925 [Abstract] [Full Text]
Green, K. A., Cook, W. J., Sharpe, A. H., Green, W. R. (2002). The CD154/CD40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD80/CD86 Costimulatory Molecules. J. Virol. 76: 13106-13110 [Abstract] [Full Text]
Harris, D. P., Koch, S., Mullen, L. M., Swain, S. L. (2001). B Cell Immunodeficiency Fails to Develop in CD4-Deficient Mice Infected with BM5: Murine AIDS as a Multistep Disease. J. Immunol. 166: 6041-6049 [Abstract] [Full Text]
Green, K. A., Noelle, R. J., Durell, B. G., Green, W. R. (2001). Characterization of the CD154-Positive and CD40-Positive Cellular Subsets Required for Pathogenesis in Retrovirus-Induced Murine Immunodeficiency. J. Virol. 75: 3581-3589 [Abstract] [Full Text]
Alas, S., Emmanouilides, C., Bonavida, B. (2001). Inhibition of Interleukin 10 by Rituximab Results in Down-Regulation of Bcl-2 and Sensitization of B-cell Non-Hodgkin's Lymphoma to Apoptosis. Clin. Cancer Res. 7: 709-723 [Abstract] [Full Text]
Hayashi, R. J., Kanagawa, O. (1999). Unique CD4+ T cells in TCR {alpha} chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process. Int Immunol 11: 1581-1590 [Abstract] [Full Text]
de Leval, L., Colombi, S., Debrus, S., Demoitie, M.-A., Greimers, R., Linsley, P., Moutschen, M., Boniver, J. (1998). CD28-B7 Costimulatory Blockade by CTLA4Ig Delays the Development of Retrovirus-Induced Murine AIDS. J. Virol. 72: 5285-5290 [Abstract] [Full Text]
Hugin, A., Vacchio, M., Morse, H. 3rd (1991). A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice. Science 252: 424-427 [Abstract]