The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 167, 2011-2016, Copyright © 1988 by Rockefeller University Press

ARTICLES

Immunoglobulin VH genes are transcribed by T cells in association with a new 5' exon

R Baer, A Forster, I Lavenir and TH Rabbitts
Medical Research Council Laboratory of Molecular Biology, Cambridge, England.

We previously detected mRNAs in a number of human T cell lines with a probe from within the Ig VH gene locus. We now show these mRNAs consist of Ig VH genes expressed in T cells. In one human T cell line, two RNA species have been studied and found to come from transcripts of unrearranged VH segments in which the leader exon, normally associated with VH transcripts in B cells, is replaced by a novel 5' exon (ET) not encoding a hydrophobic leader peptide. In genomic DNA, this new ET exon is adjacent to a pseudo-VH gene that has not been observed in mature mRNA. This implies that RNA splicing controls association of the new exon with the expressed VH segments. Hence, VH transcription does indeed occur in T cells, but is qualitatively different from that in B cells.
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