An enhancer factor defect in a mutant Burkitt lymphoma cell line

doi:10.1084/jem.167.6.1781

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An enhancer factor defect in a mutant Burkitt lymphoma cell line

W Koch, S Candeias, J Guardiola, R Accolla, C Benoist and D Mathis
Laboratoire de Genetique Moleculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unite 184, Strasbourg.

RJ 2.2.5 is an immunoselected mutant of the Burkitt lymphoma line Raji. It fails to display MHC class II antigens at the cell surface due to a transcriptional defect. We have identified the function of a regulatory factor that is defective in RJ 2.2.5 cells; this factor is absolutely required for the activity of an MHC class II gene enhancer.
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