The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 167, 1616-1624, Copyright © 1988 by Rockefeller University Press

ARTICLES

Differential induction of H-2K versus H-2D class I major histocompatibility antigens by recombinant gamma interferon. Lack of Kk augmentation in a leukemia virus-induced tumor is due to a cis-dominant effect

WR Green, RF Rich and C Beadling
Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03756.

T-T tumor hybrids were constructed between the AKR SL3 thymoma and an H- 2-distinguishable thymoma cell line. Hybrids were stimulated with IFN- gamma to determine whether the differential augmentation of H-2D vs. H- 2K class I antigen expression by AKR SL3 in response to IFN-gamma was due to effects cis or trans to the noninducible Kk gene. For each of a large number of hybrids tested, the expression of H-2Db, Kb, and Dk, but not Kk, was substantially enhanced by murine rIFN-gamma. These results suggested that the lack of induction of the Kk gene was due to an alteration cis to Kk rather than to the presence or absence of K region-specific, trans-acting negative or positive factors, respectively.
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