A human inhibitor of tumor necrosis factor alpha

doi:10.1084/jem.167.4.1511

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A human inhibitor of tumor necrosis factor alpha

P Seckinger, S Isaaz and JM Dayer
Department of Medicine, University Hospital, Geneva, Switzerland.

Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of a family of negative feedback-regulating molecules interfering with cytokines actions.
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