Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets

doi:10.1084/jem.167.2.345

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Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets

A Lanzavecchia, S Abrignani, D Scheidegger, R Obrist, B Dorken and G Moldenhauer
Basel Institute for Immunology, Switzerland.

We found that three tumor patients treated with mouse mAbs have T cells that recognize processed mouse Ig on autologous APC in a class II- restricted fashion, and we have shown that mouse mAbs directed against various cell surface molecules can be used as antigens to focus these T cells on an MHC class II-positive target of choice.
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