A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor

doi:10.1084/jem.167.2.315

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A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor

JT Sowder, CL Chen, LL Ager, MM Chan and MD Cooper
Cellular Immunobiology Unit, University of Alabama, Birmingham 35294.

This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells by approximately 3 d. Unlike their mammalian counterpart, TCR1+ cells constitute a relatively large subpopulation of peripheral T cells in mature chickens. These results suggest a phylogenetically important role for this receptor in T cell development and function.
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Six, A., Rast, J.�P., McCormack, W.�T., Dunon, D., Courtois, D., Li, Y., Chen, C.-l.�H., Cooper, M.�D. (1996). Characterization of avian T-cell receptor gamma �genes. Proc. Natl. Acad. Sci. USA 93: 15329-15334 [Abstract] [Full Text]
Carding, S R, Kyes, S, Jenkinson, E J, Kingston, R, Bottomly, K, Owen, J J, Hayday, A C (1990). Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.. Genes Dev. 4: 1304-1315 [Abstract]
Matis, L., Fry, A., Cron, R., Cotterman, M., Dick, R., Bluestone, J. (1989). Structure and specificity of a class II MHC alloreactive gamma delta T cell receptor heterodimer. Science 245: 746-749 [Abstract]
Strominger, J. (1989). Developmental biology of T cell receptors. Science 244: 943-950 [Abstract]
Janis, E., Kaufmann, S., Schwartz, R., Pardoll, D. (1989). Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science 244: 713-716 [Abstract]
Tonegawa, S., Berns, A., Bonneville, M., Farr, A., Ishida, I., Ito, K., Itohara, S., Janeway, C.A. Jr., Kanagawa, O., Katsuki, M., Kubo, R., Lafaille, J., Mombaerts, P., Murphy, D., Nakanishi, N., Takagaki, Y., Van Kaer, L., Verbeek, S. (1989). Diversity, Development, Ligands, and Probable Functions of {gamma}{delta} T Cells. Cold Spring Harb Symp Quant Biol 54: 31-44 [Abstract]
Hunig, T., Tiefenthaler, G., Lawetzky, A., Kubo, R., Schlipkoter, E. (1989). T-cell Subpopulations Expressing Distinct Forms of the TCR in Normal, Athymic, and Neonatally TCR {alpha}{beta}-suppressed Rats. Cold Spring Harb Symp Quant Biol 54: 61-68 [Abstract]
Cooper, M.D., Bucy, R.P., George, J.F., Lahti, J.M., Char, D., Chen, C.-L.H. (1989). T-cell Development in Birds. Cold Spring Harb Symp Quant Biol 54: 69-73 [Abstract]