Isolation and characterization of a light chain variable region gene for human rheumatoid factors

doi:10.1084/jem.166.6.1900

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Isolation and characterization of a light chain variable region gene for human rheumatoid factors

PP Chen, DL Robbins, FR Jirik, TJ Kipps and DA Carson
Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037.

Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain- associated 6B6.6 CRI.
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