The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 166, 1573-1578, Copyright © 1987 by Rockefeller University Press

ARTICLES

Inhibition of suppressor T lymphocytes by murine interferon beta

DM Sahasrabudhe
Cancer Center, University of Rochester School of Medicine and Dentistry, New York 14642.

We have presented data showing that IFN-beta at 1,000 U/mouse i.v. inhibits the generation of Ts-mediated tolerance to dinitrofluorobenzene (DNFB) and abrogates the transfer of suppression by Ts. We have also presented data showing that IFN-beta up to 10,000 U/mouse i.v. has no adverse effect on sensitization and elicitation. IFN-beta appears to be a suitable agent for evaluation as an adjunct in the immunotherapy of Ts inducing tumors.
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