Journal of Experimental Medicine, Vol 166, 1567-1572, Copyright © 1987 by Rockefeller University Press
Identification of the sequence required for expression of the 2H4 epitope on the human leukocyte common antigens
M Streuli, T Matsuyama, C Morimoto, SF Schlossman and H Saito
Division of Tumor Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
The anti-2H4 antibody, which subdivides the T4+ population of human T
lymphocytes into T4+, 2H4+ suppressor-inducer cells and T4+, 2H4- helper
cells, recognizes an epitope on a subset of the human leukocyte common
antigens (LCAs). LCAs are a family of cell surface glycoproteins generated
from a single gene by the differential usage of three exons near the
NH2-terminus. Using cDNA clones corresponding to four of the different
forms of LCA molecules, extracellular domains of the LCA molecules were
synthesized in vitro. Immunoprecipitation of these molecules with the
anti-2H4 antibody demonstrated that exon A is required for the expression
of the 2H4 epitope.
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