Journal of Experimental Medicine, Vol 166, 1198-1203, Copyright © 1987 by Rockefeller University Press

ARTICLES

Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/lpr mice express L3T4

DA Jabs and RA Prendergast
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

The lacrimal gland inflammatory lesions and renal vasculitic lesions of autoimmune MRL/lpr mice were analyzed for the lymphocyte subsets present. The majority of cells were Thy-1.2+ T cells (mean, 85%) of the L3T4+ helper T phenotype (mean, 64 and 58%, respectively). Lesser numbers of Lyt-2+ suppressor/cytotoxic T cells, B cells, and macrophages were present. The finding that the majority of lymphocytes in both the lacrimal gland inflammatory lesions and renal vasculitis of MRL/lpr mice expressed L3T4 suggests that these cells may be capable of responding to antigen presentation and that an active immunologic response occurs at these sites.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Jabs, D. A., Prendergast, R. A., Campbell, A. L., Lee, B., Akpek, E. K., Gerard, H. C., Hudson, A. P., Whittum-Hudson, J. A. (2007). Autoimmune Th2-Mediated Dacryoadenitis in MRL/MpJ Mice Becomes Th1-Mediated in IL-4 Deficient MRL/MpJ Mice. IOVS 48: 5624-5629 [Abstract] [Full Text]  
• Vinay, D. S., Kim, J. D., Asai, T., Choi, B. K., Kwon, B. S. (2007). Absence of 4 1BB Gene Function Exacerbates Lacrimal Gland Inflammation in Autoimmune-Prone MRL-Faslpr Mice. IOVS 48: 4608-4615 [Abstract] [Full Text]  
• Jabs, D. A., Gerard, H. C., Wei, Y., Campbell, A. L., Hudson, A. P., Akpek, E. K., Lee, B., Prendergast, R. A., Whittum-Hudson, J. A. (2004). Inflammatory Mediators in Autoimmune Lacrimal Gland Disease in MRL/Mpj Mice. IOVS 45: 2293-2298 [Abstract] [Full Text]  
• Jabs, D. A., Prendergast, R. A., Rorer, E. M., Hudson, A. P., Whittum-Hudson, J. A. (2001). Cytokines in Autoimmune Lacrimal Gland Disease in MRL/MpJ Mice. IOVS 42: 2567-2571 [Abstract] [Full Text]  
• Wang, X., Kumanogoh, A., Watanabe, C., Shi, W., Yoshida, K., Kikutani, H. (2001). Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. Blood 97: 3498-3504 [Abstract] [Full Text]  
• Jabs, D. A., Lee, B., Whittum-Hudson, J., Prendergast, R. A. (2001). The Role of Fas-Fas Ligand-Mediated Apoptosis in Autoimmune Lacrimal Gland Disease in MRL/MpJ Mice. IOVS 42: 399-401 [Abstract] [Full Text]  
• Jabs, D. A., Lee, B., Whittum–Hudson, J. A., Prendergast, R. A. (2000). Th1 Versus Th2 Immune Responses in Autoimmune Lacrimal Gland Disease in MRL/Mp Mice. IOVS 41: 826-831 [Abstract] [Full Text]  
• Chan, O. T.M., Hannum, L. G., Haberman, A. M., Madaio, M. P., Shlomchik, M. J. (1999). A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus. JEM 189: 1639-1648 [Abstract] [Full Text]  
• Chan, O., J. Shlomchik, M. (1998). A New Role for B Cells in Systemic Autoimmunity: B Cells Promote Spontaneous T Cell Activation in MRL-lpr/lpr Mice. J. Immunol. 160: 51-59 [Abstract] [Full Text]  
• Kaswan, R. L., Salisbury, M.-A., Ward, D. A. (1989). Spontaneous Canine Keratoconjunctivitis Sicca: A Useful Model for Human Keratoconjunctivitis Sicca: Treatment With Cyclosporine Eye Drops. Arch Ophthalmol 107: 1210-1216 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS