The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 166, 1186-1191, Copyright © 1987 by Rockefeller University Press

ARTICLES

Cloning and sequencing of murine T3 gamma cDNA from a subtractive cDNA library

WG Haser, H Saito, T Koyama and S Tonegawa
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.

The coding sequences of the murine and human T3 gamma chains are of identical length (182 amino acids) and contain a remarkable conservation of residues. The most striking observation is the high degree of homology between the murine and human cytosolic domains (89%), suggesting that the effector function of the T3 complex may be extremely similar or identical within human and murine lymphocytes. Both murine and human T lymphocytes can express two T3 gamma mRNA transcripts, suggesting that a second polyadenylation signal is present downstream. A poly(A) tail is not found in the 3' untranslated region of the murine gamma presented here, indicating that the murine clones analyzed represent mRNA generated by reading through the overlapping poly(A) signals at position 850-860 and possibly terminating at a position that would produce the 1.0 kb transcript.
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