The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin

doi:10.1084/jem.166.4.1098

This Article

	Full Text (PDF, 1023K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Kaplan, G.
	Articles by Cohn, Z. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Kaplan, G.
	Articles by Cohn, Z. A.


Social Bookmarking

	What's this?

ARTICLES

The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin

G Kaplan, AD Luster, G Hancock and ZA Cohn
Rockefeller University, New York 10021.

Our knowledge of the induction of new molecules by IFN-gamma has led to the characterization of IP-10 and the preparation of a monospecific, polyclonal antibody. Using this reagent we have now examined inflammatory states occurring in human skin and used immunocytochemical staining for the expression of both Ia and IP-10 determinants. After evoking a delayed-type response to purified protein derivative of tuberculin (PPD), we noted the presence of IP-10 in dermal macrophages and endothelial cells. Intense staining of the basal layer of epidermal keratinocytes was prominent at 41 h, and by 1 wk the entire epidermis was staining. The comparison of the amount of IP-10 secreted by keratinocytes vs. macrophages, fibroblasts, and endothelial cells revealed that keratinocytes were by far the major producers of this molecule. The expression of Ia occurred in conjunction with IP-10. The injection of rIFN-gamma mimicked many of the features of the PPD response, including the expression of both Ia and IP-10 by epidermal keratinocytes. Coexpression was also found in the natural lesions of tuberculoid leprosy and cutaneous Leishmaniasis. However, it was absent in lepromatous leprosy, a state where activated T lymphocytes are not present. We suggest that the local production of IFN-gamma by T cells of the dermal infiltrate induces IP-10 formation in both the dermis and epidermis. IP-10 and Ia then serve as specific markers of immune IFN and its possible influence on effector cells of the cell mediated immune response.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Lalvani, A., Millington, K. A. (2008). T-cell interferon-{gamma} release assays: can we do better?. Eur Respir J 32: 1428-1430 [Full Text]
Silva, T.A., Garlet, G.P., Fukada, S.Y., Silva, J.S., Cunha, F.Q. (2007). Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease. JDR 86: 306-319 [Abstract] [Full Text]
Gorbachev, A. V., Kobayashi, H., Kudo, D., Tannenbaum, C. S., Finke, J. H., Shu, S., Farber, J. M., Fairchild, R. L. (2007). CXC Chemokine Ligand 9/Monokine Induced by IFN-{gamma} Production by Tumor Cells Is Critical for T Cell-Mediated Suppression of Cutaneous Tumors. J. Immunol. 178: 2278-2286 [Abstract] [Full Text]
Numasaki, M., Watanabe, M., Suzuki, T., Takahashi, H., Nakamura, A., McAllister, F., Hishinuma, T., Goto, J., Lotze, M. T., Kolls, J. K., Sasaki, H. (2005). IL-17 Enhances the Net Angiogenic Activity and In Vivo Growth of Human Non-Small Cell Lung Cancer in SCID Mice through Promoting CXCR-2-Dependent Angiogenesis. J. Immunol. 175: 6177-6189 [Abstract] [Full Text]
HAILU, A., VAN DER POLL, T., BERHE, N., KAGER, P. A. (2004). ELEVATED PLASMA LEVELS OF INTERFERON (IFN)-{gamma}, IFN-{gamma} INDUCING CYTOKINES, AND IFN-{gamma} INDUCIBLE CXC CHEMOKINES IN VISCERAL LEISHMANIASIS. Am J Trop Med Hyg 71: 561-567 [Abstract] [Full Text]
Rosenkilde, M. M., McLean, K. A., Holst, P. J., Schwartz, T. W. (2004). The CXC Chemokine Receptor Encoded by Herpesvirus saimiri, ECRF3, Shows Ligand-regulated Signaling through Gi, Gq, and G12/13 Proteins but Constitutive Signaling Only through Gi and G12/13 Proteins. J. Biol. Chem. 279: 32524-32533 [Abstract] [Full Text]
Angeli, V., Staumont, D., Charbonnier, A.-S., Hammad, H., Gosset, P., Pichavant, M., Lambrecht, B. N., Capron, M., Dombrowicz, D., Trottein, F. (2004). Activation of the D Prostanoid Receptor 1 Regulates Immune and Skin Allergic Responses. J. Immunol. 172: 3822-3829 [Abstract] [Full Text]
Kayali, A. G., Van Gunst, K., Campbell, I. L., Stotland, A., Kritzik, M., Liu, G., Flodstrom-Tullberg, M., Zhang, Y.-Q., Sarvetnick, N. (2003). The stromal cell-derived factor-1{alpha}/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. JCB 163: 859-869 [Abstract] [Full Text]
Stanford, M. M., Issekutz, T. B. (2003). The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro and in vivo. J. Leukoc. Biol. 74: 791-799 [Abstract] [Full Text]
Cardona, P.-J., Gordillo, S., Diaz, J., Tapia, G., Amat, I., Pallares, A., Vilaplana, C., Ariza, A., Ausina, V. (2003). Widespread Bronchogenic Dissemination Makes DBA/2 Mice More Susceptible than C57BL/6 Mice to Experimental Aerosol Infection with Mycobacterium tuberculosis. Infect. Immun. 71: 5845-5854 [Abstract] [Full Text]
Xie, J. H., Nomura, N., Lu, M., Chen, S.-L., Koch, G. E., Weng, Y., Rosa, R., Di Salvo, J., Mudgett, J., Peterson, L. B., Wicker, L. S., DeMartino, J. A. (2003). Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation. J. Leukoc. Biol. 73: 771-780 [Abstract] [Full Text]
Cristillo, A. D., Macri, M. J., Bierer, B. E. (2003). Differential chemokine expression profiles in human peripheral blood T lymphocytes: dependence on T-cell coreceptor and calcineurin signaling. Blood 101: 216-225 [Abstract] [Full Text]
Katakai, T., Hara, T., Sugai, M., Gonda, H., Nambu, Y., Matsuda, E., Agata, Y., Shimizu, A. (2002). Chemokine-independent Preference for T-helper-1 Cells in Transendothelial Migration. J. Biol. Chem. 277: 50948-50958 [Abstract] [Full Text]
Wakasugi, K., Slike, B. M., Hood, J., Otani, A., Ewalt, K. L., Friedlander, M., Cheresh, D. A., Schimmel, P. (2002). A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Proc. Natl. Acad. Sci. USA 10.1073/pnas.012602099v1 [Abstract] [Full Text]
Sauty, A., Colvin, R. A., Wagner, L., Rochat, S., Spertini, F., Luster, A. D. (2001). CXCR3 Internalization Following T Cell-Endothelial Cell Contact: Preferential Role of IFN-Inducible T Cell {alpha} Chemoattractant (CXCL11). J. Immunol. 167: 7084-7093 [Abstract] [Full Text]
Neilsen, P. O., Zimmerman, G. A., McIntyre, T. M. (2001). Escherichia coli Braun Lipoprotein Induces a Lipopolysaccharide-Like Endotoxic Response from Primary Human Endothelial Cells. J. Immunol. 167: 5231-5239 [Abstract] [Full Text]
Qiu, B., Frait, K. A., Reich, F., Komuniecki, E., Chensue, S. W. (2001). Chemokine Expression Dynamics in Mycobacterial (Type-1) and Schistosomal (Type-2) Antigen-Elicited Pulmonary Granuloma Formation. Am. J. Pathol. 158: 1503-1515 [Abstract] [Full Text]
Fahy, O., Porte, H., Senechal, S., Vorng, H., McEuen, A. R., Buckley, M. G., Walls, A. F., Wallaert, B., Tonnel, A.-B., Tsicopoulos, A. (2001). Chemokine-Induced Cutaneous Inflammatory Cell Infiltration in a Model of Hu-PBMC-SCID Mice Grafted with Human Skin. Am. J. Pathol. 158: 1053-1063 [Abstract] [Full Text]
Bekker, L.-G., Moreira, A. L., Bergtold, A., Freeman, S., Ryffel, B., Kaplan, G. (2000). Immunopathologic Effects of Tumor Necrosis Factor Alpha in Murine Mycobacterial Infection Are Dose Dependent. Infect. Immun. 68: 6954-6961 [Abstract] [Full Text]
Kutsch, O., Oh, J.-W., Nath, A., Benveniste, E. N. (2000). Induction of the Chemokines Interleukin-8 and IP-10 by Human Immunodeficiency Virus Type 1 Tat in Astrocytes. J. Virol. 74: 9214-9221 [Abstract] [Full Text]
Dixon, A. E., Mandac, J. B., Madtes, D. K., Martin, P. J., Clark, J. G. (2000). Chemokine expression in Th1 cell-induced lung injury: prominence of IFN-gamma -inducible chemokines. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L592-L599 [Abstract] [Full Text]
Albanesi, C., Scarponi, C., Sebastiani, S., Cavani, A., Federici, M., De Pita, O., Puddu, P., Girolomoni, G. (2000). IL-4 Enhances Keratinocyte Expression of CXCR3 Agonistic Chemokines. J. Immunol. 165: 1395-1402 [Abstract] [Full Text]
Tsuji, R. F., Kawikova, I., Ramabhadran, R., Akahira-Azuma, M., Taub, D., Hugli, T. E., Gerard, C., Askenase, P. W. (2000). Early Local Generation of C5a Initiates the Elicitation of Contact Sensitivity by Leading to Early T Cell Recruitment. J. Immunol. 165: 1588-1598 [Abstract] [Full Text]
Lauw, F. N., Simpson, A. J. H., Prins, J. M., van Deventer, S. J. H., Chaowagul, W., White, N. J., van der Poll, T. (2000). The CXC Chemokines Gamma Interferon (IFN-gamma )-Inducible Protein 10 and Monokine Induced by IFN-gamma Are Released during Severe Melioidosis. Infect. Immun. 68: 3888-3893 [Abstract] [Full Text]
Mazanet, M. M., Neote, K., Hughes, C. C. W. (2000). Expression of IFN-Inducible T Cell {alpha} Chemoattractant by Human Endothelial Cells Is Cyclosporin A-Resistant and Promotes T Cell Adhesion: Implications for Cyclosporin A-Resistant Immune Inflammation. J. Immunol. 164: 5383-5388 [Abstract] [Full Text]
Sleeman, M. A., Fraser, J. K., Murison, J. G., Kelly, S. L., Prestidge, R. L., Palmer, D. J., Watson, J. D., Kumble, K. D. (2000). B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR {alpha}-chemokine. Int Immunol 12: 677-689 [Abstract] [Full Text]
ROMAGNANI, P., BELTRAME, C., ANNUNZIATO, F., LASAGNI, L., LUCONI, M., GALLI, G., COSMI, L., MAGGI, E., SALVADORI, M., PUPILLI, C., SERIO, M. (1999). Role for Interactions Between IP-10/Mig and CXCR3 in Proliferative Glomerulonephritis. J. Am. Soc. Nephrol. 10: 2518-2526 [Abstract] [Full Text]
Keane, M. P., Belperio, J. A., Arenberg, D. A., Burdick, M. D., Xu, Z. J., Xue, Y. Y., Strieter, R. M. (1999). IFN-{gamma}-Inducible Protein-10 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via Inhibition of Angiogenesis. J. Immunol. 163: 5686-5692 [Abstract] [Full Text]
Juffermans, N. P., Verbon, A., van Deventer, S. J. H., van Deutekom, H., Belisle, J. T., Ellis, M. E., Speelman, P., van der Poll, T. (1999). Elevated Chemokine Concentrations in Sera of Human Immunodeficiency Virus (HIV)-Seropositive and HIV-Seronegative Patients with Tuberculosis: a Possible Role for Mycobacterial Lipoarabinomannan. Infect. Immun. 67: 4295-4297 [Abstract] [Full Text]
Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999). The T Cell-Specific CXC Chemokines IP-10, Mig, and I-TAC Are Expressed by Activated Human Bronchial Epithelial Cells. J. Immunol. 162: 3549-3558 [Abstract] [Full Text]
Agostini, C., Cassatella, M., Zambello, R., Trentin, L., Gasperini, S., Perin, A., Piazza, F., Siviero, M., Facco, M., Dziejman, M., Chilosi, M., Qin, S., Luster, A. D., Semenzato, G. (1998). Involvement of the IP-10 Chemokine in Sarcoid Granulomatous Reactions. J. Immunol. 161: 6413-6420 [Abstract] [Full Text]
Majumder, S., Zhou, L. Z.-H., Chaturvedi, P., Babcock, G., Aras, S., Ransohoff, R. M. (1998). p48/STAT-1{alpha}-Containing Complexes Play a Predominant Role in Induction of IFN-{gamma}-Inducible Protein, 10 kDa (IP-10) by IFN-{gamma} Alone or in Synergy with TNF-{alpha}. J. Immunol. 161: 4736-4744 [Abstract] [Full Text]
Andrew, D. P., Chang, M.-s., McNinch, J., Wathen, S. T., Rihanek, M., Tseng, J., Spellberg, J. P., Elias, C. G. III (1998). STCP-1 (MDC) CC Chemokine Acts Specifically on Chronically Activated Th2 Lymphocytes and Is Produced by Monocytes on Stimulation with Th2 Cytokines IL-4 and IL-13. J. Immunol. 161: 5027-5038 [Abstract] [Full Text]
Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., Sahagan, B. G., Neote, K. (1998). Interferon-inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3. JEM 187: 2009-2021 [Abstract] [Full Text]
Gangur, V., R. Simons, F. E., Hayglass, K. T. (1998). Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-{gamma} over IL-4 responses. FASEB J. 12: 705-713 [Abstract] [Full Text]
Sallusto, F., Lenig, D., Mackay, C. R., Lanzavecchia, A. (1998). Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes. JEM 187: 875-883 [Abstract] [Full Text]
Biddison, W. E., Cruikshank, W. W., Center, D. M., Pelfrey, C. M., Taub, D. D., Turner, R. V. (1998). CD8+ Myelin Peptide-Specific T Cells Can Chemoattract CD4+ Myelin Peptide-Specific T Cells: Importance of IFN-Inducible Protein 10. J. Immunol. 160: 444-448 [Abstract] [Full Text]
Teruya-Feldstein, J., Jaffe, E. S., Burd, P. R., Kanegane, H., Kingma, D. W., Wilson, W. H., Longo, D. L., Tosato, G. (1997). The Role of Mig, the Monokine Induced by Interferon-gamma , and IP-10, the Interferon-gamma -Inducible Protein-10, in Tissue Necrosis and Vascular Damage Associated With Epstein-Barr Virus-Positive Lymphoproliferative Disease. Blood 90: 4099-4105 [Abstract] [Full Text]
Szczepanik, M., Anderson, L. R., Ushio, H., Ptak, W., Owen, M. J., Hayday, A. C., Askenase, P. W. (1996). {gamma}{delta} T Cells from Tolerized {alpha}{beta} T Cell Receptor (TCR)-deficient Mice Inhibit Contact Sensitivity-Effector T Cells In Vivo, and Their Interferon-{gamma} Production In Vitro. JEM 184: 2129-2140 [Abstract] [Full Text]
Feliciani, C., Gupta, A.K., Saucier, D.N. (1996). Keratinocytes and Cytokine/Growth Factors. CROBM 7: 300-318 [Abstract] [Full Text]
Strieter, R. M., Polverini, P. J., Kunkel, S. L., Arenberg, D. A., Burdick, M. D., Kasper, J., Dzuiba, J., Van Damme, J., Walz, A., Marriott, D., Chan, S.-Y., Roczniak, S., Shanafelt, A. B. (1995). The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis. J. Biol. Chem. 270: 27348-27357 [Abstract] [Full Text]
Wakefield, T. W., Strieter, R. M., Wilke, C. A., Kadell, A. M., Wrobleski, S. K., Burdick, M. D., Schmidt, R., Kunkel, S. L., Greenfield, L. J. (1995). Venous Thrombosis�Associated Inflammation and Attenuation With Neutralizing Antibodies to Cytokines and Adhesion Molecules. Arterioscler. Thromb. Vasc. Bio. 15: 258-268 [Abstract] [Full Text]
Groves, D.T., Jiang, Y. (1995). Chemokines, a Family of Chemotactic Cytokines. CROBM 6: 109-118 [Abstract] [Full Text]
Smoller, B. R., McNutt, N. S., Gray, M. H., Krueger, J., Hsu, A., Gottlieb, A. B. (1990). Detection of the Interferon-gamma-Induced Protein 10 in Psoriasiform Dermatitis of Acquired Immunodeficiency Syndrome. Arch Dermatol 126: 1457-1461 [Abstract]
Gottlieb, A. B., Krueger, J. G. (1990). HLA Region Genes and Immune Activation in the Pathogenesis of Psoriasis. Arch Dermatol 126: 1083-1086 [Abstract]
Nickoloff, B. J. (1988). Role of Interferon-{gamma} in Cutaneous Trafficking of Lymphocytes With Emphasis on Molecular and Cellular Adhesion Events. Arch Dermatol 124: 1835-1843 [Abstract]
Wakasugi, K., Slike, B. M., Hood, J., Otani, A., Ewalt, K. L., Friedlander, M., Cheresh, D. A., Schimmel, P. (2002). A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Proc. Natl. Acad. Sci. USA 99: 173-177 [Abstract] [Full Text]