The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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Journal of Experimental Medicine, Vol 166, 804-809, Copyright © 1987 by Rockefeller University Press

ARTICLES

Development of Ly-1+ B cells in immunodeficient CBA/N mice

A de la Hera, MA Marcos, ML Toribio, C Marquez, ML Gaspar and C Martinez

Spleen cells from CBA/N mice developing a systemic autoimmune disease after daily injection of CsA during an autologous bone marrow reconstitution were transferred into unmanipulated syngeneic recipients. Adoptive transfer allowed the development of Ly-1+ B cells, which shared Mac-1 differentiation antigen expression with the myelomonocytic lineage. Interestingly, expansion of formerly absent Ly- 1+ B cells was paralleled by a severe reduction in common, Ly-1-, B cell development in the recipient. We conclude that precursors for Ly- 1+ B lineage do exist in CBA/N mice.
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