A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types

doi:10.1084/jem.166.2.341

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A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types

C Transy, SR Nash, B David-Watine, M Cochet, SW Hunt 3d, LE Hood and P Kourilsky

We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.
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