Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)

doi:10.1084/jem.165.6.1737

This Article

	Full Text (PDF, 372K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Mosier, D. E.
	Articles by Morse, H. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Mosier, D. E.
	Articles by Morse, H. C., 3d


Social Bookmarking

	What's this?

ARTICLES

Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)

DE Mosier, RA Yetter and HC Morse 3d

Athymic nu/nu mice were found to be resistant to the immunodeficiency disease and lethality induced in normal mice by the injection of the LP- BM5 mixture of murine retroviruses (LP-BM5 MuLV). Susceptibility to disease induction was reconstituted by injection of nu/nu mice with purified, mature T lymphocytes. The extent of viral replication of both the ecotropic and mink cell focus forming (MCF) components of LP-BM5 MuLV was equivalent in both nu/nu and normal animals. Retrovirally- induced immunodeficiency disease in mice (MAIDS) is thus dependent upon the presence of functional T lymphocytes, and high virus titers in athymic mice have little or no effect on the immune system.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Li, W., Green, W. R. (2006). The Role of CD4 T Cells in the Pathogenesis of Murine AIDS.. J. Virol. 80: 5777-5789 [Abstract] [Full Text]
Rossi, L., Serafini, S., Franchetti, P., Casabianca, A., Orlandi, C., Schiavano, G. F., Carnevali, A., Magnani, M. (2002). Inhibition of murine AIDS by a heterodinucleotide of azidothymidine and 9-(R)-2-(phosphonomethoxypropyl)adenine. J Antimicrob Chemother 50: 639-647 [Abstract] [Full Text]
Rossi, L., Dominici, S., Serafini, S., Casabianca, A., Cerasi, A., Chiarantini, L., Celeste, A. G., Cappellacci, L., Franchetti, P., Grifantini, M., Magnani, M. (2002). Pharmacokinetic and antiretroviral activity in mice of oral [P1,P2-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine. J Antimicrob Chemother 50: 365-374 [Abstract] [Full Text]
Harris, D. P., Koch, S., Mullen, L. M., Swain, S. L. (2001). B Cell Immunodeficiency Fails to Develop in CD4-Deficient Mice Infected with BM5: Murine AIDS as a Multistep Disease. J. Immunol. 166: 6041-6049 [Abstract] [Full Text]
Hayashi, R. J., Kanagawa, O. (1999). Unique CD4+ T cells in TCR {alpha} chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process. Int Immunol 11: 1581-1590 [Abstract] [Full Text]
Tayar, L., Higo, K., Kubo, Y., Wang, Y., Lu, L.-M., Zhang, F., Iwatani, Y., Wang, L., Ono, T., Maeda, M., Sakai, H., Ishimoto, A. (1999). Induction of B-Cell Lymphoma in BALB/c Nude Mice with an Ecotropic, B-Tropic Helper Virus Present in the Murine AIDS Virus Stock. J. Virol. 73: 1640-1644 [Abstract] [Full Text]
Suzuki, K, Narita, T, Yui, R, Ohtsuka, K, Inada, S, Kimura, T, Okada, Y, Makino, M, Mizuochi, T, Asakura, H, Fujiwara, M (1997). Induction of intestinal lesions in nu/nu mice induced by transfer of lymphocytes from syngeneic mice infected with murine retrovirus. Gut 41: 221-228 [Abstract] [Full Text]
Kanagawa, O, Vaupel, B., Gayama, S, Koehler, G, Kopf, M (1993). Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS). Science 262: 240-242 [Abstract]