The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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Journal of Experimental Medicine, Vol 165, 1725-1730, Copyright © 1987 by Rockefeller University Press

ARTICLES

Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer

WM Yokoyama, F Koning, G Stingl, JA Bluestone, JE Coligan and EM Shevach

We have produced a T cell hybridoma line by fusion of an IL-2- dependent, long-term T cell receptor (TCR) gamma/delta+ Thy-1+, bone marrow-derived, dendritic epidermal cell line to the BW5147 tumor line. The resultant hybridoma was rapidly growing, lymphokine independent, and expressed T3 in association with the TCR gamma/delta heterodimer. Several subclones of the hybridoma line produced easily detectable levels of IL-2 after stimulation by anti-T3 or Con A. The availability of these cloned cell lines should greatly facilitate further functional, biochemical, and molecular studies of the TCR delta chain.
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