Journal of Experimental Medicine, Vol 165, 1230-1235, Copyright © 1987 by Rockefeller University Press

ARTICLES

The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain

I Funke, A Hahn, EP Rieber, E Weiss and G Riethmuller

The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamus and pons. CD4- specific mRNA was detected in all three subareas and in the hippocampus, while other subareas were negative. The CD4+ cells were negative with anti-T cell antibodies (anti-CD2 and anti-CD8), as well as with antimonocyte antibodies (M-M 522 and M-M 42).
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