Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA

doi:10.1084/jem.165.2.560

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Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA

JR Rodgers, R Smith 3d and RR Rich

Mtf, a cytoplasmic, probably mitochondrial factor, controls Mta polymorphism. We tested for dominance between two forms of Mtf to determine whether Mta is controlled by positive or negative genetic mechanisms. We fused Mtf-disparate cells containing distinct mtDNA markers and selected for hybrids containing both. Such mtDNA heteroplasmons codominantly and stably express alternative Mta antigens. Stable codominance excludes negative genetic mechanisms as well as a model of induced nuclear compensation, and implies Mtf controls Mta expression through a positive genetic mechanism.
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Battersby, B. J., Redpath, M. E., Shoubridge, E. A. (2005). Mitochondrial DNA segregation in hematopoietic lineages does not depend on MHC presentation of mitochondrially encoded peptides. Hum Mol Genet 14: 2587-2594 [Abstract] [Full Text]