The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 165, 531-545, Copyright © 1987 by Rockefeller University Press

ARTICLES

Molecular dissection of the murine antibody response to streptococcal group A carbohydrate

CT Lutz, TL Bartholow, NS Greenspan, RJ Fulton, WJ Monafo, RM Perlmutter, HV Huang and JM Davie

Monoclonal antibodies (mAb) to streptococcal group A carbohydrate (GAC) are encoded by a minimum of two VH, four JH, four V kappa, three J kappa, one V lambda, and one J lambda gene segments. The IdX, IdI-1, and Id5 idiotypic determinants are expressed by anti-GAC mAb and are found on free kappa chains. Each pattern of these determinants is encoded by a distinct V kappa gene segment, apparently without the requirement for a particular J kappa, VH, or JH gene segment, or somatic mutation. In contrast, the binding site-associated idiotypic determinant IdI-3a does not correlate with any single V or J gene segment.
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