Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes

doi:10.1084/jem.165.2.408

This Article

	Full Text (PDF, 480K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Gotch, F.
	Articles by Moss, B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Gotch, F.
	Articles by Moss, B.


Social Bookmarking

	What's this?

ARTICLES

Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes

F Gotch, A McMichael, G Smith and B Moss

Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1, polymerase PB2, and nucleoproteins of influenza virus in association with MHC class I antigens. These internal viral proteins were seen by CTL in conjunction with one or more of the available dependent HLA gene products. There was no detectable recognition of influenza virus surface glycoproteins in target cells.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Ishizuka, J., Grebe, K., Shenderov, E., Peters, B., Chen, Q., Peng, Y., Wang, L., Dong, T., Pasquetto, V., Oseroff, C., Sidney, J., Hickman, H., Cerundolo, V., Sette, A., Bennink, J. R., McMichael, A., Yewdell, J. W. (2009). Quantitating T Cell Cross-Reactivity for Unrelated Peptide Antigens. J. Immunol. 183: 4337-4345 [Abstract] [Full Text]
Naumova, E. N., Gorski, J., Naumov, Y. N. (2009). Two Compensatory Pathways Maintain Long-Term Stability and Diversity in CD8 T Cell Memory Repertoires. J. Immunol. 183: 2851-2858 [Abstract] [Full Text]
Manuel, E. R., Charini, W. A., Sen, P., Peyerl, F. W., Kuroda, M. J., Schmitz, J. E., Autissier, P., Sheeter, D. A., Torbett, B. E., Letvin, N. L. (2006). Contribution of T-Cell Receptor Repertoire Breadth to the Dominance of Epitope-Specific CD8+ T-Lymphocyte Responses. J. Virol. 80: 12032-12040 [Abstract] [Full Text]
Facchinetti, A., Santa, S. D., Mezzalira, S., Rosato, A., Biasi, G. (2005). A Large Number of T Lymphocytes Recognize Moloney-Murine Leukemia Virus-Induced Antigens, but a Few Mediate Long-Lasting Tumor Immunosurveillance. J. Immunol. 174: 5398-5406 [Abstract] [Full Text]
Bontkes, H. J., de Gruijl, T. D., Schuurhuis, G. J., Scheper, R. J., Meijer, C. J. L. M., Hooijberg, E. (2002). Expansion of dendritic cell precursors from human CD34+ progenitor cells isolated from healthy donor blood; growth factor combination determines proliferation rate and functional outcome. J. Leukoc. Biol. 72: 321-329 [Abstract] [Full Text]
Golovina, T. N., Wherry, E. J., Bullock, T. N. J., Eisenlohr, L. C. (2002). Efficient and Qualitatively Distinct MHC Class I-Restricted Presentation of Antigen Targeted to the Endoplasmic Reticulum. J. Immunol. 168: 2667-2675 [Abstract] [Full Text]
Boon, A. C. M., de Mutsert, G., Graus, Y. M. F., Fouchier, R. A. M., Sintnicolaas, K., Osterhaus, A. D. M. E., Rimmelzwaan, G. F. (2002). The Magnitude and Specificity of Influenza A Virus-Specific Cytotoxic T-Lymphocyte Responses in Humans Is Related to HLA-A and -B Phenotype. J. Virol. 76: 582-590 [Abstract] [Full Text]
Seo, S. H., Webster, R. G. (2001). Cross-Reactive, Cell-Mediated Immunity and Protection of Chickens from Lethal H5N1 Influenza Virus Infection in Hong Kong Poultry Markets. J. Virol. 75: 2516-2525 [Abstract] [Full Text]
Voeten, J. T. M., Bestebroer, T. M., Nieuwkoop, N. J., Fouchier, R. A. M., Osterhaus, A. D. M. E., Rimmelzwaan, G. F. (2000). Antigenic Drift in the Influenza A Virus (H3N2) Nucleoprotein and Escape from Recognition by Cytotoxic T Lymphocytes. J. Virol. 74: 6800-6807 [Abstract] [Full Text]
Doan, T., Herd, K., Street, M., Bryson, G., Fernando, G., Lambert, P., Tindle, R. (1999). Human Papillomavirus Type 16�E7 Oncoprotein Expressed in Peripheral Epithelium Tolerizes E7-Directed Cytotoxic T-Lymphocyte Precursors Restricted through Human (and Mouse) Major Histocompatibility Complex Class I Alleles. J. Virol. 73: 6166-6170 [Abstract] [Full Text]
Jameson, J., Cruz, J., Ennis, F. A. (1998). Human Cytotoxic T-Lymphocyte Repertoire to Influenza A Viruses. J. Virol. 72: 8682-8689 [Abstract] [Full Text]
Lalvani, A., Brookes, R., Hambleton, S., Britton, W. J., Hill, A. V.S., McMichael, A. J. (1997). Rapid Effector Function in CD8+ Memory T Cells. JEM 186: 859-865 [Abstract] [Full Text]
Moss, B (1991). Vaccinia virus: a tool for research and vaccine development. Science 252: 1662-1667 [Abstract]