Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation

doi:10.1084/jem.164.5.1773

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Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation

SM Friedman, JA Jover, EK Chartash and MK Crow

We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E- 11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed.
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