Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis

doi:10.1084/jem.164.5.1389

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Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis

CR Bartram, JW Janssen, R Becher, A de Klein and G Grosveld

We report on a Ph+ chronic myelocytic leukemia (CML) case, cytogenetically characterized by the occurrence of a second Philadelphia (Ph) chromosome in lymphoid blast crisis of T cell lineage. In situ hybridization analyses showed a deletion of translocated c-abl sequences, present on the Ph during chronic state, from both Ph in acute state. Moreover, Southern blot analyses of blastic cells exhibited a rearrangement within bcr, but a deletion of 5' bcr sequences, and Northern blots failed to detect the hybrid 8.5 kb bcr/c-abl transcript usually observed in Ph+ CML.
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Tkachuk, D., Westbrook, C., Andreeff, M, Donlon, T., Cleary, M., Suryanarayan, K, Homge, M, Redner, A, Gray, J, Pinkel, D (1990). Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization. Science 250: 559-562 [Abstract]